含钙镁生物敷料对氢氟酸烧伤的疗效  

The efficacy of biological dressing containing calcium and megnesium on the management of hydrafluoric acid burns

作　　者：王凌峰[1] 胡国林[1] 张志坚[1] 巴特[1] 荣志东[1] 王宏[1] 张军[1] 曹胜军[1] 张国华[1] 

机构地区：[1]内蒙古医学院第三附属医院烧伤科,包头014010

出　　处：《中华烧伤杂志》2007年第1期49-51,共3页Chinese Journal of Burns

基　　金：内蒙古卫生厅基金（2001008）

摘　　要：目的观察大鼠及人氢氟酸烧伤后局部应用“含钙镁生物敷料”（吸附钙、镁离子液后与戊二醛交联的绵羊真皮）的疗效，为临床治疗氢氟酸烧伤寻找更好的方法。方法将Wistar大鼠分成对照组（24只）、不治疗组（32只）、湿敷A组（32只）、生物敷料A组（32只）。后3组大鼠制成3cm×3cm的氢氟酸Ⅲ度烧伤模型，设伤后4、8、24、72h为观察时相点（每时相点8只）。生物敷料A组伤后应用“含钙镁生物敷料”覆盖创面并定期更换，湿敷A组、不治疗组、对照组则分别代以“湿敷液”或等渗盐水纱布湿敷。计算各组大鼠死亡率、进行组织病理学观察、测定血钙浓度。将46例氢氟酸烧伤患者分为湿敷B组与生物敷料B组，两组创面参照动物实验进行对比用药并观察疗效。结果对照组、不治疗组、湿敷A组、生物敷料A组大鼠的死亡率分别为0、31．2％、15．6％、6．2％。不治疗组大鼠伤后创面进行性加深，生物敷料A组与湿敷A组相对而言局部损伤略轻。对照组大鼠各时相点血钙浓度均高于其余3组，生物敷料A组各时相点均高于不治疗组与湿敷A组。伤后8、24h，生物敷料A组血钙浓度分别为（2．215±0．008）、（2．216±0．008）mmoL／L，不治疗组为（1．813±0．017）、（1．912±0．013）mmoL／L，湿敷A组为（2．015±0．006）、（2．018±0．010）mmoL／L，生物敷料A组与后两组比较，差异有统计学意义（P＜0．01）。生物敷料B组患者创面用药的镇痛效果及后期愈合情况明显优于湿敷B组。结论“含钙镁生物敷料”可用于氢氟酸烧伤后的急救和局部创面的后续治疗。Objective To observe the efficacy of biological dressing containing calcium and megnesian（sheep dermis absorbing calcium and megnesian and cross-link with glutaraldehyde）on the management of hydrofluoric acid burns in rats and patients. Methods Wister rats were randomly divided into A （ n = 24, normal control, with isotonic saline dressing after burns）, B（n = 32, with isotonic saline dressing treatment after hydrofluoric acid burns）, C （n = 32, with wet-dressing treatment after hydrofluoric acid burns） and D（ n = 32, with biological dressing treatment after hydrofluoric acid burns） groups. The rats in the latter 3 groups were inflicted with 3 cm×3 cm TBSA full-thickness burns, and Mortality, concentration of blood calcium , histopathological observation were carried out at 4,8,24 and 72 postburn hours（ PBH）, with 8 rats at each time-points. In addition, 46 patients with hydrofluoric acid burns were divided into E （with wetdressing treatment） and F（with biological dressing treatment ）groups to compare the curative effect. Resuhs The mortality in A, B, C, D groups were 0,31.2% , 15.6% ,6.2% , respectively. The wound in B group was deepened gradually after burns, but that in D group was slighter when compared with that in C group. The concentration of blood calcium in A group was higher than that in B, C and D groups at each time-points, and that in D groups was higher than that in B and C groups. The concentration of blood calcium in D group a.t 8 and 24 PBH were [ （2.215 ± 0. 008 ） , （2. 216 ± 0. 008） mmol/L ] , which were obviously higher than those in B [ （1.813 ±0.017） ,（1.912 ±0.013）mmol/L ]and C[ （2.015 ±0.006） ,（2.018 ± 0. 010）mmol/L] groups,（ P 〈 0.01 ）. The clinical outcome in E group was much better than that in F group. Conclusion Biological dressing containing calcium and megnesium can be applied in the emergency management and following treatment after hydrofluoric acid burns.

关 键 词：烧伤 化学 氢氟酸 钙 镁 生物敷料 

分 类 号：R686[医药卫生—骨科学]