产后甲状腺炎病程中淋巴细胞亚群、活化T细胞及调节性T细胞的动态变化  

Dynamic changes of peripheral lymphocyte subsets, activated T cells and regulatory T cells in the course of postpartum thyroiditis

作　　者：李晨阳[1] 李玉姝[1] 关海霞[1] 范晨玲[1] 丛琪[2] 滕颖[2] 欧阳煜宏[2] 单忠艳[1] 滕卫平[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001 [2]沈阳市第五人民医院妇产科

出　　处：《中华内分泌代谢杂志》2007年第1期64-66,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（30240013,30370680）;辽宁省科技计划项目基金（2003225005）;辽宁省教育厅课题基金（202013158）

摘　　要：应用免疫荧光染色流式细胞技术对20例临床产后甲状腺炎（PPT），7例亚临床PPT及23例健康对照产妇分别检测了产后1年中外周血淋巴细胞CD3、CD4、CD8亚群，活化T细胞（CD3^＋HLADR^＋）及调节性T细胞（CD4^＋CD25^＋）的动态变化。PPT患者产后3个月时CD4^＋T淋巴细胞数明显低于其他月份，活化T细胞数目明显增加。正常产妇产后3个月及6个月CD25^＋调节性T细胞数量显著增加，而PPT患者产后3个月时调节性T细胞百分比低于6个月和9个月时点。提示PPT的发生可能与CD4^＋T细胞亚群的减少和调节性T细胞的数目减少有关。Twenty clinical postpartum thyroiditis （PPT） patients, 7 subclinical PPT patients and 23 normal subjects were tested for peripheral blood lymphocyte subsets （CD3, CIM, CDS）, activated T cell （CD3 ^＋ HLA-DR^＋ ） and regulatory T cells （ CD4^＋ CD25 ^＋ ） during the first postpartum year by flow cytometry. The lowest CD4^＋ T cell subset and a raised percentage of activated T cell were observed at 3 months postpartum in PPT patients. Although there was no difference in percentage of regulatory T cell in normal postpartum women during different months, it was lower at 3 months postpartum than at 6 and 9 months postpartum in PPT patients （ paired t test, P 〈0.01）. In conclusion, diminished CD1^＋ T cell, decreased regulatory T cell, and raised activated T cell were observed in PPT, which were associated with the pathogenesis of PPT.

关 键 词：甲状腺炎 产后 T淋巴细胞亚群 

分 类 号：R686[医药卫生—骨科学]