突触体素在甲状腺功能减退大鼠脑海马发育期的表达  

Expression of synaptophysin in the developmental hippocampus of hypothyroid rats

作　　者：练涛[1] 张丽丽[2] 李昭瑛[1] 

机构地区：[1]山西医科大学第一附属医院内分泌科,太原030001 [2]晋城煤业集团总医院内分泌科

出　　处：《中华内分泌代谢杂志》2007年第1期72-74,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：探讨甲状腺激素对发育关键期大鼠海马各区突触体素表达的作用和影响，结果提示在脑发育关键期，甲状腺激素水平的减少改变了海马各区突触体素mRNA的表达和时相性，进而影响了该区域突触的发生及相关神经回路的建立。The effects of thyroid hormone on the synaptophysin （syn） expression were studied in the developmental period of rat hippocampus. The results suggest that the thyroid hormone reduction leads to the change of syn mRNA expression in the rat hippocampus and further affects development of synapse and establishment of related nerve circuit there.

关 键 词：甲状腺激素类 甲状腺功能减退症 突触 海马 突触体素 

分 类 号：R686[医药卫生—骨科学]