辛伐他汀抑制心肌梗死后心肌细胞凋亡及改善心功能的实验研究  

Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction

作　　者：叶强[1] 覃数[1] 雷寒[1] 胥雪莲[1] 蒋正英[1] 

机构地区：[1]重庆医科大学附属第一医院心内科,重庆400016

出　　处：《重庆医科大学学报》2007年第4期407-409,共3页Journal of Chongqing Medical University

摘　　要：目的:观察辛伐他汀对心肌梗死后心肌细胞凋亡及心功能的影响。方法:结扎大鼠左冠状动脉前降支造成心肌梗死模型,实验组给予药物处理(辛伐他汀40mg/kg),7天后,TUNEL法检测心肌组织中的凋亡心肌细胞,超声检测左心室功能参数,生化法检测血脂水平。结果:辛伐他汀组较心肌梗死组在梗死区、梗死周边区、远离梗死区凋亡心肌细胞显著减少(P<0.05),左心室功能改善(P<0.05),血脂水平没有显著性差异(P>0.05)。结论:辛伐他汀抑制心肌梗死后心肌细胞凋亡,改善心功能。Objective：To investigate the effect of simvastatin on cardiomyocyte apoptosis and cardiac dysfuction after myocardial infarction.Method：Simvastatin was administrated to the rats with myocardial infarction which was modeled by left anterior descending coronary artery ligation. After 7days, the apoptotic myocyte cells were quantified by TUNEL staining;left ventricular function index was measured by echocardiography and the level of serum lipid was measured by biochemical method.Results： Compared with infarction group, apoptotic myocyte cells in simvastatin group significantly decreased in infarction zone,border zone and non-infarction zone（P〈0.05）,and left ventricular function was improved significantly（P〈0.05 ）.There was no difference in the level of serum lipid between the groups （P〉0.05）.Conclusion：Simvastatin inhibits cardiomyocyte apoptosis and improves cardiac function after myocardial infarction.

关 键 词：辛伐他汀 心肌梗死 凋亡 

分 类 号：R542.22[医药卫生—心血管疾病]