圆窗置管微泵灌注地塞米松治疗难治性突发性感音神经性聋  

Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss

作　　者：孙霞玲[1] 任基浩[1] 卢永德[1] 殷团芳[1] 伍伟景[1] 唐月英[1] 胡彬雅[1] 

机构地区：[1]中南大学湘雅二医院耳鼻咽喉科,长沙410011

出　　处：《临床耳鼻咽喉头颈外科杂志》2007年第4期146-148,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的：观察圆窗内置管微泵灌注地塞米松治疗难治性突发性感音神经性聋（突聋）的疗效。方法：13例常规方法治疗4．8周无效的突聋患者，作外耳道皮瓣，圆窗置管经微泵灌注地塞米松，每次2．5mg，维持1h，每天2次，连续给药1周。用药期间观察记录听力改变、耳鸣和眩晕等情况。结果：13例患者治疗完成后1个月纯音测听检查：显效2例，0．25～4．00kHz听阈平均提高30．5dB；有效3例，平均提高16．7dB,无效8例，有效率38．5％（5／13）。结论：圆窗置管微泵灌注地塞米松治疗突聋的方法，能保证药物持续泵入和高浓度作用于内耳，优于鼓膜穿刺注药；操作稍复杂，但创伤小，耗费不高，为常规方法治疗无效的突聋患者提供了再次治疗获效的机会。Objective ： To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss （SSNHL）. Method： Dexamethasone （2.5 mg） was perfused transtympanically through round window catheter by Micro-infusion pump. The perfusion was taken twice a day and continued for an hour each time, for a total of 7 days. Result： Thirteen patients have been followed up for 1 month. Five of them （38. 5%） were demonstrated a 17 -54 dB improvement in pure-tone threshold average （PTA）. The other 8 patients （61.5 %） had no effect. Conclusion： Round window catheter placement with dexamethasone perfusion is a cost-effective and useful treatment for SSNHL patients who had no effect through conventional therapy, although hearing thresholds of these patients had hardly improved to normal levels.

关 键 词：聋 突发性 地塞米松 圆窗 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]