丙咪嗪配合认知疗法治疗抑郁症对照研究  

Comparative Study of Imipramine Combined with Cognitive-Behavioral Therapy in the Treatment of Depressive Patients

作　　者：杨伟 刘小琴 李晓玲 李红辉 廖秋莲 孙艳 袁春梅 

机构地区：[1]湖南省娄底市康复医院,湖南娄底417000

出　　处：《中国民康医学》2007年第5期175-177,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:评价丙咪嗪配合认知疗法对抑郁症的疗效。方法:将90例抑郁症患者随机分为3组,A组(认知疗法治疗组)30例,B组(丙咪嗪治疗组)30例,C组(丙咪嗪+认知疗法治疗组)30例,疗程6周,采用Ham ilton抑郁量表(HAMD)、抑郁自评量表(SDS)和副反应量表(TESS)在治疗前和治疗后2、4、6周末评定疗效和不良反应。结果:三组病人在治疗后4周时,A、C两组减分与B组减分差异有显著性(P<0.05);治疗6周时A、B两组差异无显著性(P>0.05),C组效果显著优于A、B两组(P<0.01),且C组丙咪嗪剂量和TESS评分明显低于B组。结论:丙咪嗪配合认知疗法治疗抑郁症是一种经济、安全有效、依从性好的方法。Objective：To assess the efficacy of imipramine combined with cognitive - behavioral therapy （CBT） in the treatment of depressive patients. Methods ：90 depressive patients were randomized into A group（ CBT group）（ n = 30 ）, B group （Imipramine group ）（ n = 30）and C group（ Imipramine combined with CBT group）（ n = 30） and studied for 6weeks . HAMD,SDS and TESS were used to assess the efficacy and side effects before and 2 weeks ,4 weeks and 6weeks after the treatment. Results： by the end of 4 weeks, there was significant difference in efficacy between A,C groups and B groups（P 〈0.05） ,by the end of 6 weeks, there was significant difference in efficacy between c group and A,B groups ,there was no significant difference in efficacy between A and B group （P 〉 0.05）, and the doses of imipramine and the TESS scores of C group were significantly lower than that of B group. Conclusions-Imipramine combined with CBT was an economic, convenient and safe treatment in depressive patient.

关 键 词：抑郁症 认知疗法 丙咪嗪 治疗 

分 类 号：R971.43[医药卫生—药品] R749.42[医药卫生—药学]