奥派与利培酮治疗精神分裂症临床对照研究  

A Comparative study of Aripiprazole versus Risperdal in patients with schizophrenia

作　　者：赵淑敏[1] 杜波[1] 栗克清[1] 田国庆[1] 刘杰[1] 宁征远[1] 刘建丛[1] 张旭静[1] 

机构地区：[1]河北省第六人民医院,河北保定071000

出　　处：《中国民康医学》2007年第5期195-197,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:以利培酮为对照,检验奥派(阿立哌唑)治疗精神分裂症的临床疗效及对各症状群的作用特点和不良反应。方法:将符合入组标准的80例精神分裂症患者随机分为阿立哌唑组40例与利培酮组40例进行为期8周的治疗。采用阳性与阴性症状量表(PANSS)、治疗副反应量表(TESS)评定疗效和不良反应。并采用放射免疫法于治疗前和治疗后2、4、8周末分别测定血清PRL水平。结果:8周末PAN-SS的减分率,阿立哌唑组与利培酮组分别为(69.46±20.18)%和(68.57±20.83)%。PANSS总分及阳性症状分、阴性症状分、一般病理分治疗前后均有显著性差异(P<0.01),但两组之间无明显差异。用TESS评定两药不良反应,阿立哌唑组评分为(3.23±2.67),利培酮组为(3.93±5.79),不良反应轻微。8周末血清PRL水平,阿立哌唑组(12.33±12.18)μg/L,与治疗前比较差异无显著性(P>0.05);利培酮组(120.35±75.64)μg/L,与治疗前比较差异有显著性(P<0.01)。两组比较差异有显著性(P<0.01)。结论:阿立哌唑临床疗效好,不良反应轻微,是一种较为理想的抗精神病药。Objective：To evaluate the efficacy and safety of Aripiprazole treatment in patients with schizophrenia. Methods：80 patients with schizophrenia were randomly divided into Aripiprazole （n = 40） and Risperdal（ n = 40）group. Antipsychotic efficacy was assessed using the Positive and Negative symptom scale（PANSS） ,Antipsychotic tolerability was assessed by Treatment Emergent Symptom Scale（TESS）. The serum prolactin level was respectively measured at pre - treatment and the 2nd, 4th, 8th week. Results： As compared with the baseline scores, PANSS reduction was （ 69.46 ± 20. 18 ） % in Aripiprazole group, and （ 68.57 ± 20.83 ） % in Risperdal group. The PANSS scores as well as positive subscale scores and negative subscale scores decreased significantly after 8 weeks treatment（ P 〈 0. 01 ）, but no significant difference between the 2 groups. No serious adverse events were found during the treatment. The PRL was（ 12.33 ± 12.18 ） μg/L in Aripiprazole group, compared （ 120.35 ± 75.64 ） μg/L in Risperdal group. There was significant difference between the 2 groups（ P 〈0. 01 ）. There was no obvious difference between the base line and 8th week end point PRL in Aripiprazole group. Conclusions： Aripiprazole has reliable effectiveness, fewer side effects, and may be a suitable therapy in the treatment of schizophrenia.

关 键 词：奥派 利培酮 精神分裂症 治疗 

分 类 号：R971.4[医药卫生—药品] R749.3[医药卫生—药学]