三氟甲磺酸盐在(E)-6-(3-甲基-4-苯磺酰基-2-丁烯基)-2,3,4,5-四甲氧基甲苯合成中的应用  

Preparation of (E)-6-(3-methyl-4-benzenesulfonyl-2-butenyl)-2,3,4,5-tetramethoxytoluene in the presence of trifluoromethanesulfonic Salt

作　　者：林京都[1] 郑云峰[1] 李景华[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032

出　　处：《浙江工业大学学报》2007年第2期190-193,共4页Journal of Zhejiang University of Technology

摘　　要：目前,三氟甲磺酸盐催化的四甲氧基甲苯(Ⅱ)与烯丙基衍生物(Ⅲ)的反应,可在比较温和的条件下进行,并能取得较好的收率.通过对各种三氟甲磺酸盐的选择比较,筛选出Yb(OTf)3作为催化剂,并考察了催化剂用量、反应时间的影响,以及催化剂的回收再利用.确定了制备辅酶Q关键中间体(E)-6-(3-甲基-4-苯磺酰基-2-丁烯基)-2,3,4,5-四甲氧基甲苯(Ⅰ)的较佳工艺路线.In the presence of trifluoromethanesulfonic salt, tetramethoxytoluene （ Ⅱ ） reacted with allylic derivatives （Ⅲ）to afford the aimed product in moderate to high yields under moderate condition. Activities of different trifluoromethanesulfonic salt catalysts had been compared. The best one is Yb（OTf）3. The effect of the catalysts amount, the reaction time, the catalyst recovery and its catalytic activity had been investigated. An efficient synthetic method for preparation of （E）- 6-（3-methyl-4-benzenesulfonyl-2-butenyl）-2,3,4,5-tetramethoxytoluene, which is the key intermediate of coenzyme Q, was provided.

关 键 词：2 3 4 5-四甲氧基甲苯 三氟甲磺酸盐 辅酶Q中间体 

分 类 号：O621.259.4[理学—有机化学]