多囊卵巢综合征患者胰岛素敏感性测定及其相关因素分析  

Analysis of insulin sensitivity in patients with polycystic ovary syndrome and its association with correlative factors

作　　者：黄健康[1] 李启富[1] 丘彦[2] 任伟[1] 程庆丰[1] 汪志红[1] 高虹[1] 青华[1] 刘秀容[1] 张素华[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016 [2]重庆医科大学附属第一医院妇产科,400016

出　　处：《中国糖尿病杂志》2007年第2期70-72,共3页Chinese Journal of Diabetes

摘　　要：目的测定多囊卵巢综合征(PCOS)患者的胰岛素敏感性(IS),并分析其相关影响因素。方法将观察对象分为PCOS肥胖组(10例)、PCOS非肥胖组(28例)和正常对照组(9例),IS用两步法高胰岛素-正葡萄糖钳夹技术评估。结果(1)PCOS两组患者的葡萄糖利用率M值明显低于对照组(P均<0.01),肥胖的PCOS患者M值降低更明显。(2)多元线性回归分析显示游离睾酮及BMI与M值负相关(P<0.05)。结论非肥胖和肥胖PCOS患者均存在明显的胰岛素抵抗,PCOS患者IS与游离睾酮及BMI密切相关。Objective To measure insulin sensitivity in patients with polycystic ovary syndrome （PCOS） and analyze its associations with correlative factors. Methods The subjects were divided into three groups： obese PCOS（n= 10）, non-obese PCOS（n= 28） and control group（n= 9）. And the insulin sensitivity was assessed by two-step hyperinsulinemic-euglycemic clamp. Results （1） Insulin sensitivity （M value） was significantly lower in obese PCOS subjects than that in other two groups （all P〈0.01）. The M value in obese PCOS subjects was even more lower than that in non-obese PCOS subjects （P〈0.05）. （2） Stepwise regression analysis showed that M150-180 value was significantly associated with free testosterone （FT） and BMI. Conclusions Both non-obese and obese PCOS women have insulin resistance, and the insulin sensitivity of PCOS patients is negatively associated with serum FT and BMI.

关 键 词：多囊卵巢综合征 钳制技术 胰岛素敏感性 

分 类 号：R711.75[医药卫生—妇产科学]