氟哌啶醇季铵盐衍生物(F_2)对缺血再灌注心律失常的拮抗作用  

Effects of Quaternary Ammonium Salt Derivative(F_2) of Haloperidol on Ischemia-reperfusion Induced Arrhythmia

作　　者：高分飞[1] 李海青[1] 石刚刚[1] 黄展勤[1] 周燕琼[1] 张艳美[1] 刘幸平[1] 

机构地区：[1]汕头大学医学院药物研究室,广东汕头515041

出　　处：《汕头大学医学院学报》2007年第1期15-17,20,共4页Journal of Shantou University Medical College

基　　金：国家自然科学基金(30672465);广东省自然科学基金重点项目(06118928);汕头市重点科技计划项目(2006)

摘　　要：目的:研究氟哌啶醇季铵盐衍生物(F2)对心肌缺血再灌注引发的心律失常的拮抗作用。方法:采用大鼠Langendorff灌流心脏模型,通过结扎冠状动脉左前降支缺血20 min,解除结扎再灌注,可引出长时间(至少5 min)室性心动过速,在灌流液中加入不同浓度F2,观察其对室性心动过速的拮抗作用。结果:F2可浓度依赖地翻转缺血再灌注引发的室性心动过速,半最大效应浓度为0.46μmol/L。结论:F2对大鼠心脏缺血再灌注心律失常具有拮抗作用。Objective： To study the antagonistic effects of quatemary ammonium salt derivative（F2）of haloperidol on ischemia-reperfusion induced arrhythmia. Methods： Using the Langendorff-perfused rat heart model, the left anterior descending coronary artery was ligated for 20 minutes before the release of the ligature. The antiarrhythmic effect of F2 was tested after ventricular tachycardia had been induced and persisted for at least 5 minutes. Results： F2 can concentration-dependently convert the ventricular tachyarrhythmias induced by ischemia-reperfusion, the concentration of EC50 was 0.46 μmol/L. Conclusion： F2 can antagonize the arrhythmias induced by ischemia-repeffusion in rat heart.

关 键 词：氟哌啶醇季铵盐衍生物 心律失常 缺血再灌注 

分 类 号：R971.4[医药卫生—药品]