异丙嗪对大鼠局灶性脑缺血损伤的保护作用  

The Neuron-protective Effect of Promethazine on Local Cerebral Ischemia Injury in Rats

作　　者：范开明[1] 黄燕虹[1] 叶志刚[1] 万震威[1] 胡峥嵘[1] 

机构地区：[1]粤北人民医院麻醉科,广东韶关512026

出　　处：《汕头大学医学院学报》2007年第1期40-41,64,共3页Journal of Shantou University Medical College

摘　　要：目的:观察异丙嗪对大鼠脑缺血损伤病理变化及神经功能的影响。方法:用改良的Longa氏法制备大鼠可再灌注大脑中动脉闭塞模型。大鼠随机分为缺血2 h后再灌注1、6 h,1、3、7 d对照组,并与之时间点相对应的异丙嗪组,对比观察各组脑缺血再灌注(IR)后的脑梗死灶体积并对神经功能缺损进行评分。结果:异丙嗪能显著改善IR 1 d后大鼠神经功能缺损症状及脑梗死灶(P<0.05)。结论:异丙嗪可阻抑大鼠局灶性脑缺血神经元的损伤并可发挥脑保护作用。Objective： To observe the effect of promethazine on local cerebral ischemia injury in rats. Methods： Modified Longa＇s method was used to make rats＇models with reversible middle cerebral artery occlusion（MCAO）. Rats were randomly divided into 5 control groups（reperfusion for one hour, 6 hours, one day, 3 and 7 days following MCAO for 2 hours） and 5 promethazine groups with the same time point, then the infarction volume was measured and the neurologic dysfunction was scored. Results： Rats with infarctions and disorders in neurological function one day after IR. Scores and volume of infarctions reduced significantly in promethazine groups（P 〈 0.05）. Conclusion： Promethazine can prevent the injury of neuron after local cerebral ischemia in rats and produce the neuron-protective effects.

关 键 词：异丙嗪 脑缺血再灌注损伤 神经细胞保护 

分 类 号：R971.2[医药卫生—药品] R743.31[医药卫生—药学]