单甲脒动物代谢的研究  

METABOLISM OF N'ε-(2,4-DIMETHYLPHENYL)-N-METHYLFORMAMIDINE BY RATS IN VIVO

作　　者：竺廼恺 杜秀英[1] 王淑琴[1] 夏晞娟[1] 徐维并[1] 

机构地区：[1]中国科学院生态环境研究中心,北京100085

出　　处：《环境化学》1996年第6期547-551,共5页Environmental Chemistry

基　　金：国家自然科学基金

摘　　要：采用气相色谱/傅立叶红外光谱和气相色谱/质谱仪分析大鼠肝脏中单甲脒的代谢产物.证明大鼠经口摄入单甲脒后,在肝脏中迅速代谢,其代谢中间产物为2,4-二甲基苯胺和含酰胺基的化合物.N'-(2,4-dimethylphenyl)-N-methyIformamidine is a new type of organic-nitrogen insecticide and miticide. GC/FTIR and GC/MS was applied to analyse the metabolites of N'-(2, 4-dimethylphenyl)-N-methylformamidine in rat's livers. After N'-(2, 4-dime-thylphenyl)-N-methylformamidine was administered orally to rats, it was metabolized rapidly in the liver. The middle metabolites were 2,4-dimethylbenzenamine and the compounds with radical of -CONH2.

关 键 词：农药 单甲脒 二甲基苯胺 大鼠 气相色谱 

分 类 号：X592.032[环境科学与工程—环境工程]