生长激素和生长抑素联合应用对重症急性胰腺炎患者肠黏膜屏障保护作用的研究  

Effect of somatostatin combined with growth hormone on intestinal mucosal barrier of patients with severe acute pancreatitis

作　　者：黄鹏[1] 熊炯炘[1] 王春友[1] 吴河水[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胰腺外科,武汉430022

出　　处：《临床外科杂志》2007年第3期178-180,共3页Journal of Clinical Surgery

摘　　要：目的评价生长抑素和生长激素联合应用对重症急性胰腺炎(SAP)肠黏膜屏障损害的治疗作用。方法采用随机对照分组的临床研究,将58例确诊为SAP的患者分为治疗组(生长抑素组)和生长抑素联合生长激素治疗组(联合治疗组),其中生长抑素组31例,联合治疗组27例。检测血浆二胺氧化酶和D-乳酸,并动态观察APACHEⅡ评分。结果与生长抑素组相比,联合治疗组血浆二胺氧化酶、D-乳酸水平自入院第4天起至入院第14天较生长抑素组显著降低,两组差异有统计学意义(P<0.05);APACHEⅡ评分明显改善。结论生长抑素和生长激素联合应用可加强肠道黏膜屏障功能、减轻细菌和内毒素易位,显著改善SAP患者的预后。Objective To assess the therapeutic efficacy of somatostatin （SS） combined with growth hommone （GH） on intestinal mucosa barrier of patients with severe acute pancreatitis （SAP）. Methods By using random controlled trail,58 patients were divided imo SS group （31 cases） and SS combined with GH group （27 cases）. Levels of serum DAO and D- Lactated were measured,and changes of APACHE II were observed. Results Compared with SS group,serum DAO and D- Lactated from the day 4 to 14 after admission were significantly reduced,and APACHE Ⅱ markedly improved as compared with those in SS combined GH group. Conclusion The combined use of SS and GH could improve imestinal mucosa barrier function, decrease bacteria translocation and systemic endotoxin level,and significantly improve the prognosis of SAP patients.

关 键 词：重症急性胰腺炎 生长抑素 生长激素 治疗 

分 类 号：R657.51[医药卫生—外科学]