应用四种用药方案进行冻融胚胎移植的临床结局比较  

Comparison of clinical outcomes of four protocols for frozen-thawed embryo transfer cycle

作　　者：陈士岭[1] 何锦霞[1] 宋华东[1] 黎淑贞[1] 刘晓宁[1] 李红[1] 邢福祺[1] 

机构地区：[1]南方医科大学南方医院妇产科,广东广州510515

出　　处：《南方医科大学学报》2007年第3期303-306,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(30470657)~~

摘　　要：目的比较冻融胚胎移植(FET)四种用药方案的临床结局,探讨如何选择恰当的FET子宫内膜准备方案。方法对用于FET子宫内膜准备的四种临床用药方案419个周期进行回顾性分析,比较自然周期、激素替代周期(HRT)、促排卵(hMG)周期和自然周期+hCG这四种方案对临床妊娠率、种植率、早期流产率、异位妊娠率、继续妊娠率和分娩率的影响上是否存在差异。结果四种用药方案在不孕年龄、不孕年限、移植胚胎个数和子宫内膜厚度上均无统计学差异,在临床妊娠率、种植率、早期流产率、异位妊娠率、继续妊娠率和分娩率上的差异亦无统计学意义。结论四种用药方案用于FET的子宫内膜准备获得了良好的临床结局,应根据患者情况选择进行FET的个性化用药方案。Objeelive To compare the clinical outcome of 4 protocols of frozen-thawed embryo transfer cycle to select the optimal endometrial preparation method for frozen-thawed embryos transfer. Methods A retrospective analysis of the 4 clinical protocols was conducted including natural cycle, down-regulated hormone replacement treatment （HRT） cycle, hMG cycle and natural cycle＋hCG in endometrial preparation for 419 frozen-thawed embryos transfer cycle, and the clinical pregnancy rate, implantation rate, early abortion rate, ectopic pregnancy rate, ongoing pregnancy rate and delivery rate were compared between the 4 protocols. Results There was no significant difference between the 4 groups with different clinical protocols in age, duration of infertility, reason of infertility, number of embryo transferred and endometrial thickness. The 4 protocols differed little in the implantation rate, clinical pregnancy rate, biochemical pregnancy rate, early abortion rate, ectopic pregnancy rate, ongoing pregnancy rate and delivery rate in the four clinical protocols. Conclusion The 4 clinical protocols for frozen-thawed embryos transfer all have favorable clinical outcome, and choice of a specific protocol should be made according to the a comprehensive consideration of the individual conditions of the patient.

关 键 词：冻融胚胎 胚胎移植 内膜准备 妊娠率 种植率 用药方案 

分 类 号：R714.8[医药卫生—妇产科学]