正常和HBsAg阳性孕妇胎盘中TLR3检测分析  

Distribution of TLR3 in human placenta from normal and HBsAg-positive pregnant women

作　　者：原琛利[1] 王素萍[1] 宋秀霞[2] 

机构地区：[1]山西医科大学流行病学教研室,太原030001 [2]山西省太原市传染病医院妇产科

出　　处：《中国公共卫生》2007年第3期287-288,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(30070699);山西省自然科学基金(20001063)

摘　　要：目的了解Toll样受体(TLR3)在正常和HBsAg阳性孕妇胎盘各层细胞中的分布,探索TLR3在胎盘HBV感染中的作用。方法免疫组织化学(SABC)法检测19例正常孕妇胎盘和102例HBsAg阳性孕妇胎盘组织中TLR3和HBsAg。结果TLR3在正常孕妇胎盘阳性率100.00%(19/19),HBsAg阳性孕妇胎盘阳性率74.51%(76/102);102例HBsAg阳性孕妇胎盘发生乙型肝炎病毒(HBV)感染为33例;TLR3在正常孕妇胎盘和HBsAg阳性孕妇胎盘上的分布差异有统计学意义(χ2=6.17,P=0.012);TLR3与胎盘HBV感染的关系差异有统计学意义(χ2=13.581,P=0.000 1)。结论TLR3可能是HBsAg阳性孕妇胎盘发生HBV感染的一个保护因素(OR=0.180,95%CI=0.069-0.469)。Objective To investigate the presence and distribution of toll-like receptors 3（TLR3） in term human placenta from normal and HBsAg-positive pregnant women and to explore the role of TLR3 in placenta HBV infection. Methods TLR3 and HBsAg in placentas of 19 normal and 102 HBsAg-positive pregnant women were detected by immunohistochemistry SABC. Results The positive rate of TLR3 in normal pregnant women was 100.00 % （19/19） and 74.51% （76/102） in HBsAg-positive pregnant women;33 of 102 placentas were infected by HBsAg; There was statistical difference in distribution of TLR3 between placentas of normal and HBsAg-positive pregnant women（X^2 = 6.17, P = 0. 012） ; the relationship between TLR3 and HBV infection was significant（X^2 = 13. 581, P 〈 0. 000 1 ）. Conclusion TLR3 is a protect factor of HBV infection in placentas（ OR = 0. 180, 0. 069-0. 469）.

关 键 词：TLR3 乙型肝炎病毒(HBV) 胎盘 

分 类 号：R711.7[医药卫生—妇产科学]