中华芦荟多糖对小鼠急性肝损伤保护作用  

Protective effect of polysaccharide from Aloe vera L var Chinensis on acute liver injury in mice

作　　者：张晓林[1] 杨安平[1] 

机构地区：[1]佛山科学技术学院医学院,佛山528000

出　　处：《中国公共卫生》2007年第3期339-340,共2页Chinese Journal of Public Health

基　　金：广东省中医药管理局科研课题(402020)

摘　　要：目的研究中华芦荟多糖(AP)对急性肝损伤的保护作用及其作用机制。方法选用昆明种小鼠,1.79,3.58,7.17 mg/(kg.bw)3种剂量中华芦荟多糖分别灌胃给药,用四氯化碳(CCl4)造成急性肝损伤,测定血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肝脏组织中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果3种剂量的中华芦荟多糖均能显著地降低小鼠血清ALT和AST活性,提高小鼠肝脏SOD活性,降低肝脏MDA含量。结论中华芦荟多糖能够对由四氯化碳(CCl4)所造成的急性肝脏损伤起保护作用,其机制与提高小鼠的抗氧化能力有关。Objective To study the protective effect and mechanism of polysaccharide from aloe vera L vat on the acute liver injury of mice. Methods Kunming mice were chosen to do the experiment, The mice were administrated orally with polysaccharide at the dose of 1.79, 3.58 and 7.17 mg/（ kg· bw） respectively. The liver in jury model was established by CCl4 intoxication mice. Alanine transaminase（ALT） and aspartate transaminase（AST） in serum, superoxidase（SOD） and malondialdehyde（MDA） content in hepatic tissue were measured. Results Polysaccharide at the different dose can decrease ALT, AST activities in serum, MDA content, and increase SOD activity in hepatic tissue. Conclusion Polysaccharide from aloe vera L var possesses a protective effect on the acute liver injury of CCl4 intoxication mice by antioxidation.

关 键 词：中华芦荟多糖 肝脏 血清酶 超氧化物歧化酶 丙二醛 

分 类 号：R994.6[医药卫生—毒理学]