潍坊市区人群麻疹抗体水平及麻疹疫苗强化免疫血清学效果监测  

作　　者：徐斌[1] 董爱萍[2] 

机构地区：[1]潍坊市疾病预防控制中心,山东省潍坊市261041 [2]潍坊市人民医院,山东省潍坊市261041

出　　处：《医学动物防制》2007年第1期5-7,共3页Journal of Medical Pest Control

摘　　要：为了解潍坊市麻疹疫苗(MV)强化免疫的效果和人群麻疹抗体水平,在2个区随机抽取767名0-39岁健康人,应用酶联免疫吸附试验检测麻疹IgG抗体。结果:767人中抗体阳性595人,阳性率77.57%,几何平均滴度(GMT)1:783。以1-12岁儿童抗体阳性率高(85.71%-98.44%),GMT则从6岁开始下降至中低等水平,抗体阳性率有随年龄增长而下降的趋势。观察MV初种8-12月龄儿童94人,免疫成功率为96.81%;MV复种5-7岁儿童93人,免疫成功率61.29%;免疫后抗体GMT分别比免疫前提高28.4倍和3.1倍。不论是初种或复种,免疫前抗体处于中低等水平者其免疫成功率显著高于免疫前高抗体水平者。This paper reported the results of measles antibody detection in 767 persons aged 0-39 years old in weifang city. The overall antibody positive rate was 77.57% and the antibody geometric mean titres （GMT） was 1： 783. Seropositive rate of 1-12 years old age groups were the highest （8,5.71% -98. 44 %） than the other groups. After the age of 6, antibody GMT was shown to be middle and low level. The seropositive rate of measles antibody dropped along with the growth of age. 94 persons aged 0 year and 93 persons aged 5-7 years randomly selected from 767 persons were observed after vaccinating measles vaccine. The immune successful rate of them was 96.81% and 61. 29% respectively. The GMT increased by 28. 4 times and 3.1 times respeetively. Whether basic immunization or reimmunization, there was a negative relationship between immunization successful rate and the measles antibody titer prior to immunization.

关 键 词：麻疹疫苗 免疫效果 IGG抗体 监测 

分 类 号：R511.1[医药卫生—内科学]