CatSper与精子超活化  

CatSper and Sperm Hyperactivation

作　　者：孔丽娟[1] 杨媛媛[1] 王根林[1] 

机构地区：[1]南京农业大学动物科技学院,江苏南京210095

出　　处：《中华男科学杂志》2007年第2期164-167,共4页National Journal of Andrology

基　　金：国家自然科学基金(30471243)

摘　　要：精子超活化是受精前精子运动方式发生改变的过程,Ca2+参与这一过程,诱导精子鞭毛发生不对称运动。CatSper是近来发现的一类仅存于精子鞭毛上的阳离子通道,作为Ca2+内流的通道参与精子超活化过程。现就目前CatSper在小鼠上的研究现状,对其蛋白结构、分布、在精子超活化过程中调节Ca2+的作用以及尚待解决的问题作一综述。Elevation of sperm Ca^2＋ seems to be responsible for an asymmetric form of motility called hyperactivation, which is first seen near the time of fertilization. CatSper family proteins are putative cation channels expressed exclusively in the membranes of the sperm flagellum. Hyperactivation requires CatSper proteins, which presumably serve as the route of entry for Ca^2＋ that operates directly on the flagellar axoneme to increase waveform asymmetry. In this article, the structure of mouse CatSper, the role it plays in sperm hyperactivation and the unsolved problems are described. NatlJAndrol,2007,13（2） ：164-167

关 键 词：CatSper 精子超活化 CAMP 信号转导 小鼠 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]