气道正压通气治疗高血压伴阻塞性睡眠呼吸暂停低通气综合征  

Efficacy of Positive Airway Pressure on Patients with Hypertension Complicated with Obstructive Sleep Apnea-Hypopnea Syndrome

作　　者：徐江祥[1] 刘志强[1] 黄小红[1] 胡星兰[1] 王霞[1] 夏斌[1] 曹玲玲[1] 蔡平[1] 汤杰[1] 徐保朝 余达训 

机构地区：[1]九江市第一人民医院一病区,江西九江332000

出　　处：《中华高血压杂志》2007年第1期49-52,共4页Chinese Journal of Hypertension

摘　　要：目的经鼻持续气道正压通气(nCPAP)治疗高血压合并阻塞性睡眠呼吸暂停低通气综合征(OS-AHS)患者,以评价该疗法对血压和睡眠呼吸监测参数的影响。方法临床确诊合并OSAHS的高血压患者,随机分为治疗组和对照组,治疗组在给予常规药物(抗高血压药、抗动脉硬化药物)治疗的同时进行nCPAP治疗,对照组仅给予常规药物治疗。30天后,观察两组治疗前后血压、睡眠呼吸监测参数变化。结果高血压合并OSAHS患者共60例,治疗组和对照组各30例;治疗后治疗组的收缩压(SBP)、舒张压(DBP)、脉压(PP)、心率(HR)、睡眠呼吸暂停低通气指数(AHI)、最长呼吸暂停时间和最低脉搏容积血氧饱和度(SpO2min),与对照组比较差异有统计学意义(P<0.05);部分患者降压药物减量或停用,仅用nCPAP治疗就能维持正常血压。结论nCPAP是非药物治疗合并OSAHS高血压患者的一种安全有效方法。Objective To evaluate the efficacy of nasal continuous positive airway pressure （nCPAP） on the blood pressure and the parameters of sleep respiration in patients of hypertension complicated with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods Sixty eases of hypertension complicated with OSAHS were randomly divided into treatment group n = 30 and control group n： 30. nCPAP and routine drug treatment （ant;hypertensive and anti-atherosclerosis medications） were administered in the treatment group, while only routine drug treatment was given in the control group. Blood pressure and parameters of sleep respiration in two groups were compared before and after treatment. Results SBP, DBP, pulse pressure, heart rate, apnea hypopnea index （ AHI） , maximum apnea duration, and minimum pulse oxygen saturation （ SpO2 min ） were significantly improved （P〈0. 05 ） after nCPAP treatment. The ant;hypertensive medications were decreased or even discontinued in some patients, in whom only nCPAP was able to keep the normal BP. Conclusion nCPAP was a safe, effective treatment in hypertension complicated with OSAHS.

关 键 词：高血压 阻塞性睡眠呼吸暂停低通气综合征 气道正压通气 

分 类 号：R544.1[医药卫生—心血管疾病] R766[医药卫生—内科学]