A new convenient asymmetric approach to herbarumin Ⅲ  

作　　者：Xue Song Chen Shi Jun Da Li Hong Yang Bo Yan Xu Ztfi Xiang Xie Ying Li 

机构地区：[1]The State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China

出　　处：《Chinese Chemical Letters》2007年第3期255-257,共3页中国化学快报（英文版）

基　　金：The project was supported by the National Natural Science Foundation of China(No.20672050).

摘　　要：The asymmetric total synthesis of herbarumin Ⅲ 3, a naturally occurred phytotoxin, along with 8-epi-herbantmin Ⅲ 22, was succeeded in 12 steps from n-butyraldehyde based on Brown＇s asymmetric allylation, taking modified Julia olefination and Yamaguchi＇s macro-lactonization as key steps.The asymmetric total synthesis of herbarumin Ⅲ 3, a naturally occurred phytotoxin, along with 8-epi-herbantmin Ⅲ 22, was succeeded in 12 steps from n-butyraldehyde based on Brown＇s asymmetric allylation, taking modified Julia olefination and Yamaguchi＇s macro-lactonization as key steps.

关 键 词：Herbarumin Ⅲ Asymmetric allylation Modified Julia olefination Yamaguchi＇s macro-lactonization 

分 类 号：R996.2[医药卫生—毒理学]