成人隐匿性自身免疫糖尿病与2型糖尿病动脉内中膜厚度的研究  

The comparison of artery intima-medial thickness between latent autoimmune diabetes in adults and type 2 diabetes

作　　者：王晓华[1] 周智广[2] 李霞[2] 周菁[1] 曾亚[1] 林健[2] 杨治芳[2] 颜湘[2] 

机构地区：[1]长沙市中心医院内分泌科,湖南长沙410011 [2]中南大学湘雅二医院内分泌代谢研究所,湖南长沙410011

出　　处：《中国实用内科杂志》2007年第6期444-446,共3页Chinese Journal of Practical Internal Medicine

基　　金：湖南省科技厅科研基金(02SSY3065);湖南省医药卫生科研基金(B2005166)

摘　　要：目的探讨成人隐匿性自身免疫糖尿病(LADA)与2型糖尿病(T2DM)患者亚临床动脉粥样硬化(AS)的差异及其影响因素。方法选取2002年8月至2005年2月中南大学湘雅二医院70例LADA患者,检测其颈总动脉及股动脉内中膜厚度(IMT),与匹配的T2DM患者进行比较。采用多元线性回归分析LADA患者IMT增加的危险因素。结果LADA和T2DM患者亚临床AS发生率相似(11.4%对17.1%,P>0.05)。多元线性回归分析显示,年龄、胰岛素抵抗指数(HOMA-IR)、吸烟及低密度脂蛋白胆固醇(LDL-C)是颈总动脉IMT增加的主要影响因素;年龄、HOMA-IR、性别及LDL-C是股动脉IMT增加的主要影响因素。结论该组LADA与T2DM患者亚临床AS发生率相似。LDL-C、吸烟、性别、年龄及HOMA-IR可能是LADA患者IMT增加的主要影响因素。Objective To explore and compare the prevalence of subclinical atherosclerosis between LADA and type 2 diabetes, and investigate the risk factors of artery intima-medial thickness （IMT） in LADA patients. Methods The CCAIMT and FA-IMT were observed in 70 LADA （ GADA positive） patients and 70 T2DM （ GADA negative） subjects matched with age, gender and duration. Risk factors of IMT were estimated with multiple linear regression analysis. Results The prevalence of subclinical atherosclerosis between LADA cases and type 2 diabetic patients was similar （ 11.4% VS. 17. 1% ,P 〉0. 05）. In LADA patients,muhipe linear regression analysis showed that the risk factors related to the intima media thickness of common carotid artery were age, smoking and LDL-C and the risk factors related to the intima medial thickness of femoral artery were age, sex and LDL-C. Conclusion The prevalence of subclinical atheroscleresis between LADA and type 2 diabetes is similar. LDL-C,age,sex and smoking may be the risk factors of subclinical AS in LADA patients.

关 键 词：糖尿病 动脉内中膜厚度 隐匿性自身免疫糖尿病 成人 2型糖尿病 亚临床动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]