内皮素、降钙素基因相关肽对2型糖尿病肾病的诊断价值  

The Diagnosis Value of Endothelin, Calcitonin Gene-related peptide and the Ratio in Diabetic Nephropathy

作　　者：李鲁生[1] 赵鑫[1] 迟流萤[1] 杨希秀[1] 毛红宇[1] 

机构地区：[1]济南市中心医院,山东济南250013

出　　处：《中国辐射卫生》2007年第1期34-36,共3页Chinese Journal of Radiological Health

摘　　要：目的采用放射免疫分析法(RIA)通过对2型糖尿病患者尿白蛋白和血浆内皮素(ET)、降钙素基因相关肽(CGRP)含量的检测,探讨血管神经肽对2型糖尿病肾病的诊断价值。方法以2型糖尿病肾病为研究对象,选择54例健康人作为对照组,确诊的124例2型糖尿病患者为观察组,以尿白蛋白排泄率(uAER)作为分组标准,将观察组分为糖尿病尿白蛋白正常组(A组);早期糖尿病肾病组(B组);临床糖尿病肾衰组(C组)。结果2型糖尿病肾病患者血浆ET水平明显高于正常对照组(P<0.01),ET与uAER呈显著正相关关系(r=0.591,P<0.01)。血浆CGRP水平明显低于正常对照组,CGRP与uAER之间呈显著负相关关系(r=-0.389,P<0.05)。血浆ET、CGRP、ET/CGRP均随uAER增高而发生明显变化,但以ET/CGRP比值与uAER的关系最为密切(r=0.772,P<0.01)。结论①血浆ET、CGRP与2型糖尿病肾病呈密切相关关系,并参与了糖尿病肾病的发生和发展;②血浆ET/CGRP比值更能反映2型糖尿病肾病的严重程度;③本实验为使用外源性CGRP预防和治疗糖尿病肾病开辟了一条新的思路和方法。Objective To evaluate the diagnosis value of Endothelin（ET）, Calcitonin gene - related peptide（CGRP） and theratio in diabetic nephropathy（DN）. Methods To choose 54 healthy as the control group and 124 patients with diabetes or DN as test group. According to urinary albumin excretion rate（ uAER）, the test group was divided into three groups, which were diabetes group of normalalbuminuria（ group A ）, early DN （group B）and clinical DN ＆ renal failure group（ group C ）. Plasma concentration of ET and CGRP were measured with radioimmunossay for those in the Control group and patients with diabetes or DN. Results The level of ET was significantly higher in diabetic nephropathy than that in the control group（ P 〈 0.01 ）, and there was positive correlationbetween ET and uAER （ r = 0.591, P 〈 0.01 ）. The plasma level of CGRPwas significantly lower in diabetic nephropathy than that in the control group （P 〈 0.01 ）, and there was negative correlation between CGRP and uAER（r = -0. 389,P 〈 0.05 ）. The level of ET, CGRP and ET/CGRP ratio have evidently changed with the uAER rised. Conclusion （1）The level of ET, CGRP and type 2 diabetic nephropathy are closely related, and which probably plays a role in the development of DN. （2）ET/CGRP ratio, as a new way for diagnosis, can even more reflecte the seriousness of DN. （3）This experiment provide us a new way for the prevention and treatment of DN with extrinsic CGRP.

关 键 词：2型糖尿病肾病 尿白蛋白排泄率 内皮素 降钙素基因相关肽 放射免疫分析 

分 类 号：R817[医药卫生—影像医学与核医学]