正己烷接触工人脂质过氧化作用的调查  

STUDY ON LIPID PEROXIDATION OF WORKERS EXPOSED TO N-HEXANE

作　　者：邰昌松 丘天祥 徐小作[2] 涂程[3] 杨青[3] 王棉珍[3] 兰亚佳[3] 

机构地区：[1]深圳市宝安区公明预防保健所,深圳518106 [2]深圳市宝安区疾病预防控制中心 [3]四川大学华西公共卫生学院劳动卫生教研室

出　　处：《现代预防医学》2007年第5期893-894,897,共3页Modern Preventive Medicine

基　　金：深圳市科技局资助项目(200304262)

摘　　要：[目的]探讨正己烷对接触工人机体的脂质过氧化作用。[方法]测定接触正己烷工人的血清中丙二醛(MDA)、总抗氧化能力(T-AOC)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)的含量或活性。[结果]接触组MDA含量显著高于对照组(P=0.048),T-AOC较对照组明显降低(P﹤0.0001);接触组中CAT活性高于对照组,GSH-Px低于对照组,但不具有统计学意义。[结论]正己烷可以引起暴露工人的脂质过氧化损伤,可能在正己烷中毒中具有重要作用。[objective] To discuss lipid peroxidation of workers exposed to n-hexane. [Methods] Some indexes about lipid peroxidation such as MDA, T-AOC, SOD, GSH-Px, CAT were determined. [ ResultsJ The MDA concentration of exposure group showed an significant increase compared with control group （P = 0.048） and the T-AOC activity showed an significant decrease （P 〈 0.0001 ）; The differences of CAT and GSH-Px activity had no statistical sense. [Conclusion] N-hexane could cause lipid peroxidation damage, which maybe has important role in n-hexane toxicosis.

关 键 词：调查 正己烷 脂质过氧化 

分 类 号：R136.32[医药卫生—劳动卫生]