无创通气连接解痉剂吸入治疗COPD合并呼衰的临床观察  

Clinical observation on treating COPD with respiratory failure by non-invasive ventilation linking to antimucarinics and β_2 agonist

作　　者：王同[1] 李秀[1] 张素萍[1] 吴祖凤[1] 张春美[1] 陈若静[1] 丁震[1] 

机构地区：[1]合肥市第一人民医院呼吸科,安徽230061

出　　处：《安徽卫生职业技术学院学报》2007年第1期23-24,共2页Journal of Anhui Health Vocational & Technical College

基　　金：合肥市科协基金项目(合科[2002]54号序号5)

摘　　要：目的:观察BiPAP无创通气连接解痉剂吸入治疗慢性阻塞性肺病(COPD)急性加重合并呼衰的疗效。方法:将呼吸科住院COPD急性加重合并呼吸衰竭的患者82例,随机分成对照组和治疗组。观察患者的血气、肺功能、体征、住院时间等。结果:治疗2h和24h后,治疗组和对照组PaO2和PaCO2,呼吸频率均改善,治疗组明显优于标准组(P<0.05)。治疗72小时后,和对照组相比,治疗组FEV1明显提高(P<0.05)。治疗组患者症状改善时间、住院时间均明显缩短,降低插管率。结论:应用BiPAP无创通气连接解痉剂吸入治疗慢性阻塞性肺病急性加重合并呼衰患者,可明显提高PaO2,降低PaCO2,可改善肺功能,缩短住院时间。Objective To observe clinical effects of BiPAP non-invasive ventilation linking to antimucarinics and β2 agonist for treating COPD with respiratory failure. Methods 82 cases were randomly divided into control group and treatment group and their blood gas, pulmonary function and etc. were observed. Results 2h and 24h after treatment, treatment group had a significant improvement in PaO2 and PaCO2 level（P〈0.05）. 72h after treatment, FEV1 of treatment increased （P〈0.05）. The improvement time and hospitalization time were shortened in treatment group and rate of inserting tube was decreased, Conclusion The method of applying BiPAP non-invasive ventilation linking to antimucarinics and β2 agonist to treat COPD with respiratory failure can increase PaO2 and decrease PaCO2, improve pulmonary function and shorten hospitalization time.

关 键 词：慢性阻塞性肺病 无创通气 呼吸衰竭 

分 类 号：R563.5[医药卫生—呼吸系统]