HSCT极期口腔炎的临床研究  

HSCT oral mucositis of patients after haemopoietic stem cell transplantation

作　　者：顾道琴[1] 李娟[1] 谯川南[1] 吴云[1] 何绵玲[1] 杨晓慧[1] 李杨[1] 

机构地区：[1]安徽省立医院洁净病房,合肥230001

出　　处：《安徽卫生职业技术学院学报》2007年第1期35-36,共2页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨紫外线局部照射联合粒—巨噬细胞集落刺激因子(GM—CSF)应用于造血干细胞移植极期所致口腔黏膜炎(OM)的效果,并与常规使用的口腔药膜比较。方法:随机将30例造血干细胞移植极期发生OM的患者分为两组,一组患者在口腔溃疡处用1%的碘甘油和锡类散交替外涂,并定为对照组;另一组为试验组,用紫外线治疗仪局部照射半小时后再予GM-CSF局部外涂或将其稀释后直接含漱,比较两组口腔黏膜炎的愈合情况。结果:试验组与对照组相同部位,程度相似的OM在愈合时间上存在一定的差异(P<0.05)。结论:紫外线局部照射并联合使用GM—CSF对造血干细胞移植极期所致的OM的作用优于常规的口腔药膜治疗。Objective To evaluate the efficacy of ultraviolet rays irradiation combined with granulocytemacrophage colony stimulating factor（GM-CSF） treating on oral mucositis of patients after haemopoietic stem cell transplantation and compare with conventional treatment of oral drug membrane. Methods 30 patients were randomly divided into two groups, the experiment group was treated with ultraviolet rays irradiation combined with GM-CSF, and the control group used 1% iodoglycerin and xileisan by local application. Statistically the efficacy of the two groups were compared. Results There was significant difference between two groups for OM in same location with similar severity（P〈0.05） at healing time. Conclusion Ultraviolet rays irradiation combined with GM- CSF therapy is better than conventional drug membrane for treating post haemopoietic stem cell transplantation induced oral mucositis with the same severity of and degree.

关 键 词：紫外线 粒-巨噬细胞集落刺激因子 造血干细胞移植 口腔炎 治疗 

分 类 号：R816.98[医药卫生—放射医学]