康惠尔增强型透明贴防治静脉炎的作用机制实验研究  

An experimental study on mechanism of Comfeel plus transparent dressing to prevent and treat phlebitis of rabbits

作　　者：宁宁[1] 杨小春 陈海霞[1] 尹海林[3] 张强[4] 陈薇波[4] 

机构地区：[1]四川大学华西医院 [2]上海东方医院 [3]华西医院动物实验中心 [4]四川大学公共卫生学院

出　　处：《护理研究（上旬版）》2007年第3期592-594,共3页Chinese Nursing Researsh

摘　　要：[目的]探讨康惠尔增强型透明贴防治兔静脉炎的作用机制。[方法]将24只健康日本大耳白兔随机分成模型组、硫酸镁组和康惠尔组。采用20%甘露醇溶液静脉输注制造实验性静脉炎模型。硫酸镁组和康惠尔组于每次输液结束后5min之内分别给予25%硫酸镁涂抹和贴敷康惠尔增强型透明贴。分别于末次输液后24h、48h、72h取兔耳缘静脉组织标本,观察细胞间黏附分子-1(ICAM-1)和血管内皮生长因子(VEGF)的表达。[结果]模型组ICAM-1和VEGF表达高于康惠尔组和硫酸镁组,差异有统计学意义(P<0.05)。[结论]采用康惠尔增强型透明贴贴敷,可防治甘露醇引起的静脉炎,其防治静脉炎的作用机制可能与其抑制ICAM-1和VEGF的升高有关。Objective： To investigate the mechanism of action of Comfeel plus transparent dressing to prevent and treat phlebitis of rabbits. Method： A total of 24 healthy large - eared Japanese rabbits were divided into model group, 25 % magnesium sulfate group and Comfeel plum transparent dressing group randomly and equally 8 rabbits in each group. Experimental phlebitis models were prepared by intravenously infusing 20% mannitol for rabbits. Corresponding interventions were given for rabbits 5 minutes after transfusion in each group. Tissue specimens were collected from the auricular veins of rabbits at 24 hours, 48 hours and 72 hours after mannitol transfusion respectively. And the expression of ICAM - 1 and VEGF of these tissues were observed. Result： In terms of ICAM - 1 and VEGF expression, rabbits of model group were higher than those of Comfeel plum transparent dressing group. There was statistical significant difference between them （P 〈 0.05）. Conclusion： Comfeel plus transparent dressing could prevent and cure manicol induced phlebitis. The mechanism of it possibly is that Comfeel plus transparent .dressing can inhibit the expressions of ICAM- 1 and VEGF.

关 键 词：康惠尔增强型透明贴 静脉炎 作用机制 实验研究 

分 类 号：R472[医药卫生—护理学]