石棉改性后对大鼠致癌性的研究  

An experimental study of carcinogenic effect of modified asbestos on rats

作　　者：朱惠兰[1] 邓海金[1] 邢康吉[1] 杨贵春[1] 李明[1] 白新桂[1] 杜庆成[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,清华大学材料科学与工程系

出　　处：《中华劳动卫生职业病杂志》1996年第2期71-74,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金

摘　　要：为了探讨石棉改性后对生物体的致癌作用，采用了氯化铵（ＮＨ＿４Ｃｌ）水溶液和聚醚砜（ＰＥＳ）对川棉和茫棉两种温石棉样品进行化学和物理改性，观察其对实验大鼠胸膜内染尘产生的影响。结果表明，各石棉改性组大鼠胸膜间皮瘤诱发率均有降低，尤其是川棉化学改性组与未改性组比，差异有非常显著意义（Ｐ＜０．０１）。作者认为，化学改性使石棉中的Ｍｇ￣（２＋）等金属离子量降低，这可能是导致间皮瘤诱发率降低的一个重要原因。Two kinds of chrysotile samples(fiber length > 10μm)obtained from “Si Chuan ”and “Mang Ya”mines were both treated by chemical method using NH4Cl solution and physical method cov-ering the fibers with polyethersulphone(PES).Fibers of 50 mg were given to each rat by intrapleural in- jection.Physiological saline was used for a control group.All rats were observed for 2 years.The inci-dence of mesothelioma among all modified asbestos groups decreased,especially in those treated chemi-cally with NH4Cl solution(P < 0.01).X-ray diffraction patterns indicated that NH4Cl solution could remove Mg￣(2+) ion.It is suggested that the fall of Mg￣(2+) ion in modified asbestos might play an important role in the reduction of tumor by asbestos.

关 键 词：石棉 改性 间皮瘤 肿瘤 致癌性 

分 类 号：R135.99[医药卫生—劳动卫生] R730.2[医药卫生—公共卫生与预防医学]