硒和维生素E缺乏对大鼠胰岛功能的影响  

CHANGES OF ISLETS FUNCTION OF RATS WITH SEMISYNTHETIC DIETS DEFICIENT IN SELENIUM

作　　者：张桂珍[1] 任立群[1] 李广生[1] 王凡[1] 康德仁[1] 

机构地区：[1]白求恩医科大学地方病研究所

出　　处：《营养学报》1996年第4期441-445,共5页Acta Nutrimenta Sinica

基　　金：自然科学基金

摘　　要：以低硒酵母（Ｔｏｒｕｌａｙｅａｓｔ）及低硒玉米淀粉为主要成分配成低硒、低ＶＥ及硒和ＶＥ联合缺乏饲料喂饲大鼠，引起血清胰岛素、Ｃ肽水平显著下降（Ｐ＜０．０１），胰岛内胰岛素与Ｃ肽分泌贮备明显减少（Ｐ＜０．０１），并伴有血及胰腺组织ＧＳＨ－Ｐｘ活性显著降低（Ｐ＜０．０１），ＬＰＯ含量明显上升（Ｐ＜０．０５～０．０１），在饲料中补０．２ｍｇ／ｋｇ硒或５００ｍｇ／ｋｇＶＥ，可明显提高血清胰岛素、Ｃ肽水平（Ｐ＜０．０１），增加胰岛素与Ｃ肽分泌贮备（Ｐ＜０．０１），同时伴有血及胰腺ＧＳＨ－Ｐｘ活性水平升高与ＬＰＯ含量降低（Ｐ＜０．０５～０．０１），提示硒和ＶＥ缺乏是胰岛损害的重要病因之一。The semisynthetic selenium-deficient diet mainly consisted of Torula yeast and corn starch caused the decrease of insulin and connecting peptide(CP) concentration in serum as we11 as islets tissues of the rats.Simultaneously the decrease of GSH-Px activity and the increase of LPO contents in serum and pancreas also occurred. The diet supplemented with either selenium 0.2 mg/kg or vitamin E 500mg/kg significantly increased insulin and CP concentration in serum and their secretive storage in islets tissue of the rats(P<0.01). The results suggest that selenium or vitamin E deficiency is an important pathogeny in causing islet lesions.

关 键 词：硒 维生素E 胰岛素 

分 类 号：R591.450.2[医药卫生—内科学]