PPAR-γ2基因和β3-AR基因联合变异与新疆哈萨克族人群高血压病的关系  

Additive effects of the variants in the β3-AR and PPAR-γ2 genes on essential hypertension in Xinjiang kazakh population.

作　　者：潘慧娟 郭艳英[2] 王坤[3] 赵蕾[3] 何秉贤[3] 

机构地区：[1]深圳市南山区西丽人民医院,深圳518055 [2]新疆维吾尔自治区人民医院,乌鲁木齐830001 [3]新疆医科大学第一附属医院心血管中心,乌鲁木齐830054

出　　处：《中国优生与遗传杂志》2007年第3期19-21,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的检测新疆哈萨克族人群中β3肾上腺素能受体(β3-adrenergic receptor,β3-AR)基因Trp64Arg多态和(peroxisome proliferators-activated receptor gamme2,PPARγ2) Pro12Ala多态联合变异与高血压病的关系。方法应用聚合酶链反应和限制性片断长度多态性技术检测247例高血压病、224例血压正常高值和143例正常人的基因型,同时测定相关的生化指标,并进行病例-对照统计学分析。结果β3-AR基因Trp64Arg多态、PPARγ2基因Pro12Ala多态及两基因的联合变异的基因型和等位基因频率在三组间无统计学差异。结论β3-AR Trp64Arg多态、PPARγ2Pro12Ala多态及两基因的联合变异与哈萨克族高血压病的发生无明显关联。Objective： To investigate the additive effects of β3 - AR gene Trp64Arg variation and PPARγ2 gene Pro12Ala variation on essential hypertension in Xinjiang Kazakh Population. Methods： PCR - restriction fragment length polymorphism was used to detect the genotypes of 247 hypertensives and 224 bordertensives and 143 normotensives, and some biochemical indexes were tested. The association of the polymorphisms with essential hypertension was assessed in a ease - control study. Results ： No statistically significant differences were found in the frequencies of β3 - AR or PPARγ2 gene mutation and simultaneously two genes mutation among the three groups. Conclusion： Additive effects of the variants in the β3 - AR Trp64Arg and PPARγ2Prol2Ala are not significantly associated with essential hypertension in Xinjiang Kazakh Population.

关 键 词：高血压病 遗传多态性 Β3肾上腺素能受体基因 过氧化物酶增殖体激活受体γ2基因 哈萨克族 

分 类 号：R544.1[医药卫生—心血管疾病]