小儿热性惊厥与IL-10基因多态性的相关性研究  

A study on the association of polymorphism of IL-10 with febrile convulsion

作　　者：高博[1] 胡明双[1] 张莉[1] 

机构地区：[1]长春市儿童医院,吉林130051

出　　处：《中国优生与遗传杂志》2007年第3期24-25,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨IL-10基因启动子区1082位点基因型与小儿热性惊厥(FC)的关系。方法采用限制片断长度多态分析-聚合酶链反应方法(RFLP/PCR)对60例热性惊厥患儿和40例随机挑选健康体检的儿童的IL-10的基因启动子区1082位点基因型进行分析,筛选有意义基因型。结果热性惊厥组患儿IL-101082位点AA型分布频率为60.0%,GG分布频率为6.7%,GA分布频率为33.3%,与正常对照组比较均有显著性差异(P<0.01)。GG型与正常对照组比较亦有显著性差异(P<0.05)。结论IL-10的基因启动子区1082位点AA可能是中国北方汉族FC患儿的易感基因。IL-10基因启动子区1082位点的基因型对FC的发生、发展、治疗有重要意义。Objective： To investigate the relationship between the polymorphism of the IL - 10 gene and FC in children. Methods： Sixty children with FC serve as observing group, fourty normal newborns serve as control group. Adopting RFLP/PCR, we analysis IL - 10 1082 site gene, at last, counting distribution frequency to screen genotype of significance. Results： Of the observing group, the level of IL - 10 is higher than those of control group. The distribution frequency of the IL - 10 gene type AA, GA, and GG is 60. 0%, 33%, and 6.7% , respectively analysised by statistical method. We find that AA genotype distribution frequency is higher than control group, the difference has statistical significance. Conclusion： AA genotype is susceptibility gene. Our study result clarify that FC has close correlation to the polymorphism of IL - 10 1082 site gene.

关 键 词：儿童 热性惊厥 IL-10 基因多态性 

分 类 号：R720.597[医药卫生—急诊医学]