VEGF在不同类型子痫前期患者胎盘组织中的表达及意义  

Expression and significance of vascular endothelial growth factor in placenta from pregnancy complicated with pre-eclampsia

作　　者：苏悦[1] 顾建娟[1] 田秀春[2] 

机构地区：[1]江苏省苏北人民医院妇产科 [2]江苏省苏北人民医院病理科,江苏扬州225001

出　　处：《中国优生与遗传杂志》2007年第3期26-27,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血管内皮生长因子(VEGF)在不同类型子痫前期患者胎盘组织中的表达及意义。方法采用免疫组织化学SP法检测18例正常孕妇(对照组),36例子痫前期患者(子痫前期组,其中轻度子痫前期患者18例,重度子痫前期患者18例)胎盘组织中VEGF的表达强度。结果VEGF主要表达于胎盘绒毛滋养细胞;重度子痫前期患者胎盘绒毛滋养细胞VEGF表达强度明显低于对照组及轻度子痫前期患者(P<0.05),而轻度子痫前期患者与对照组比较,无显著性差异(P>0.05)。结论VEGF在胎盘中主要由绒毛滋养细胞分泌,子痫前期患者VEGF分泌减少,尤其是重度子痫前期的患者,这可能是引起局部胎盘绒毛及血管病变的原因。Objective： To study the expression of vascular endothelial growth factor （VEGF） in placenta from normal pregnancy and pregnancy complicated with pre - eclampsia and the significance of VEGF on the etiology of pre - eclampsia. Methods： Use the immunohistochemistry to determine the intensity of VEGF staining in placenta from 18 cases of normal pregnancy and 56 cases of pregnancies complicated with mild , severe group pre - eclampsia. Results： Immunolocalization of VEGF in all cases was observed mainly in syncytiotrophoblast. Intensity of VEGF immnostaining in syncytiotrophoblast was significantly reduced in the severe pre - eclampsia group （ P 〈 0.05 = compared with both the mild pre - eclampsia group and the normal group , while there was no qualitative differences between the mild pre - eclampsia group and the normal group （ P 〉 0. 05）. Conclusion： These results suggest that VEGF is secreted mainly by syncytiotrophoblast in human placenta and the reduced VEGF may be responsible , at least in part , for the impaired vascular development in pre - eclampsia.

关 键 词：内皮生长因子 子痫前期 胎盘 

分 类 号：R714.246[医药卫生—妇产科学]