盐酸利多卡因体外对长时间禁欲的精子运动参数的影响  

Influence of lidocaine hydrochloride on long time abstinence sperm motility in vitro

作　　者：张文权[1] 熊文琴 黄开淑[1] 谢小毛[1] 胡兰英[1] 陈红娟[1] 

机构地区：[1]湖南省常德市第一人民医院生殖医学中心,415000 [2]湖南省常德市第一中医院,415000

出　　处：《中国优生与遗传杂志》2007年第3期101-103,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨盐酸利多卡因体外对人精子运动参数的影响。方法10例健康生育男性,禁欲1个月手淫获取精液,与不同浓度的盐酸利多卡因体外孵育10min,用HTF液洗涤后重悬。采用计算机辅助的精液分析系统(computer assisted semen analysis,CASA)分别检测孵育后和洗涤重悬后的精子运动参数。结果低浓度的盐酸利多卡因对精子运动参数没有明显地影响(P>0.05),但浓度达到15mg/ml时精子的运动参数显著降低(P<0.05)。结论高浓度盐酸利多卡因能明显地抑制人精子的运动。Objective： To investigate the effects of lidocaine hydrochloride on human sperm motility in vitro. Methods ： Abstinence One month Healthy fertile Males＇ Sperm was incubated with different concentration of lidocaine hydrochloride ten minutes. Then wash- ing - up by HTF. Measurement of all sperm mobility were carried out by CASA after incubation and washing - up. Results： Sperm motility was not affected by low concentration lidocaine hydrochloride. But inhibited by 15 mg/ml lidocaine hydrochloride. Conclusion： High concentration lidocaine hydrochloride can significantly inhibit human sperm motility.

关 键 词：人精子运动参数 盐酸利多卡因 体外 

分 类 号：R698.2[医药卫生—泌尿科学]