辛伐他汀对阵发性心房颤动患者的影响  

Influence of simvastatin on patients with paroxysmal atrial fibrillation

作　　者：唐方明[1] 冷广曦[1] 包浔娜[1] 何星球[1] 

机构地区：[1]广东省农垦中心医院心血管内科,广东湛江524002

出　　处：《中国心血管杂志》2007年第1期52-54,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的了解阵发性心房颤动患者相关时间段内的血浆C-反应蛋白(CRP)水平及辛伐他汀40mg对阵发性心房颤动患者的干预作用。方法将120例阵发性心房颤动患者随机分成辛伐他汀组(Ⅰ组,n=62)和常规组(Ⅱ组,n=58),I组患者在常规抗心律失常治疗基础上每晚口服辛伐他汀40mg,同时对各患者分别于心房颤动发作时及转复窦性心律后14d、28d时检测血清中的CRP水平,并统计各患者心房颤动发作次数及每次发作的持续时间,随访时间为1年。结果各患者心房颤动发作时的CRP水平明显高于窦性心律时的CRP水平(P<0.05);试验终点时Ⅰ组患者心房颤动的累计发作次数及发作的平均持续时间明显少于Ⅱ组(P<0.05)。结论阵发性心房颤动的发生与复发可能与炎症有关,辛伐他汀具有减少心房颤动发生和复发的作用。Objective To understand the level of C- reactive protein（CRP） of patient with paroxysmal atrial fibrillation （atrial fibrillation） and the effect of simvastatin on patient with atrial fibrillation. Methods 120 atrial fibrillation patients were randomly divided into simvastatin group（ Ⅰ group, n = 62 ） and conventional group （ Ⅰ group, n = 58 ）. The patients of Ⅱ group were treated with conventional methods, patients of I group took orally 40mg simvastatin a day besides conventional treatment. The CRP level of all patients were respectively detected when atrial fibrillation occurred and 14 and 28 days after sinus rhythm recovered, the number of atrial fibrillation occurrence of each patiens was counted ,and all patients were received follow-up of 1 year. Results The level of CRP which was detected when atrial fibrillation occurred was higher than that decteded when patient had sinus rhythm （P〈0.05 ）, the aecumulative number of atrial fibrillation ocurrence in Ⅰ group was not so many as that in Ⅱ group（ P 〈 0.05 ） when the study was over. Conclusion The occurrence and recidivation of atrial fibrillation may be related with inflammation, simvastatin can reduce the occurrence and recidivation of atrial fibrillation.

关 键 词：心房颤动 C反应蛋白 辛伐他汀 

分 类 号：R541.7[医药卫生—心血管疾病]