2型糖尿病患者加用Glargine/NPH治疗对血糖波动影响的对照研究  

A compared study about the fluctuation of blood glucose in T2DM patients injected Glargine/NPH

作　　者：穆攀伟[1] 曾龙驿[1] 张国超[1] 许海霞[1] 王曼曼[1] 孙卫平[1] 傅静奕[1] 江柏泉[1] 穆曼娜[2] 陈燕铭[1] 

机构地区：[1]中山大学附属第三医院内分泌科,广东广州510630 [2]福建省三明市第一医院药剂科,福建三明365000

出　　处：《国际内科学杂志》2007年第2期65-67,共3页International Journal of Internal Medicine

摘　　要：目的比较单用口服药空腹血糖控制不佳的2型糖尿病患者加用甘精胰岛素(Glargine)或中性精蛋白锌胰岛素(NPH)后对血糖波动的影响。方法72例经口服抗糖尿病药治疗的2型糖尿病患者(FBG>7.0mmol/L,GHbA1c>7.5%),按1∶1随机分成两组,分别加用Glargine或NPH联合治疗。以空腹微量血糖(mFBG)<6.0mmol/L为目标,并监测早餐后2h微量血糖(mP1BG)、午餐后2h微量血糖(mP2BG)和晚餐后2h微量血糖(mP3BG),计算一天4次微量血糖的样本标准差(SD),以及最高和最低血糖之差(Δ)。结果两组比较Glargine组SD和Δ均较小(P<0.05),而低血糖发生率无显著差异(P>0.05)。结论单用口服药物治疗但血糖控制不佳的2型糖尿病患者加用Glargine比加用NPH更有利于血糖的平稳,且不增加低血糖的发生率。Objective To compare the fluctuation of blood glucose （BG） in the type 2 diabetes mellitus （T2DM） patients who had been treated with oral antidiabetic drugs （OADs） plused glargine or NPH. Methoils Sevenfy-two T2DM subjects whose fasting blood glucose were inadequately controlled on OADs （FBG〈7.0 mmol/L and GHbA1c 〉7.5% ） were randomly assigned into 2 groups additionally treated with glargine or NPH. The dose of insulin was titrated to achieve the target that mFBG was lower than 6. 0 mmol/L. Montoring the postbreakfast, postlunch and postdinner of BG（ recorded as raP1BG, mP2BG and mP3BG） , then calculated the sample standard deviation （SD） and the equation（△） of the highest and the lowest BG level in one day. Results In glargine group, SD and △ was smaller than those in NPH group （P 〈0.05 ）. And no difference could be found in hypoglycaemia. Conclusion Compared with adding NPH, adding glargine could make blood glucose more stable without increasing the incidence of hypoglycaemia.

关 键 词：2型糖尿病 甘精胰岛素 中性鱼精蛋白锌胰岛素 血糖波动 

分 类 号：R587.1[医药卫生—内分泌]