吲哚美辛-羟丙基-β-环糊精包合物软膏的制备及含量测定  

Preparation and Determination of Indomethacin-hydroxypropy-cyclodextrin Inclusion Complex Ointments

作　　者：余兰[1] 秦芳芳[1] 

机构地区：[1]兰州大学药学院,兰州市730000

出　　处：《中国药房》2007年第7期525-526,共2页China Pharmacy

摘　　要：目的:制备吲哚美辛-羟丙基-β-环糊精包合物软膏并建立其含量测定方法。方法:选用O/W型乳剂型软膏基质进行制备;采用紫外分光光度法测定其中吲哚美辛的含量。结果:吲哚美辛线性范围为16.76～41.91μg·mL-1(r=0.9996),平均回收率为99.53%(RSD=1.50%)。结论:该制剂制备工艺简单,含量测定方法简便、准确。OBJECTIVE： To prepare Indomethacin- hydroxypropy- cyclodextrin inclusion complex ointments and establish its assay method. METHODS： The preparation was prepared with O/W type emulsion ointment as base material, and the content of Indomethacin in which was determined by UV spectrophotometry. RESULTS： The calibration curve of Indomethacin was linear in the range of 16.76--41.91μg·mL^-1r = 0.999 6）, and its average recovery was 99.53% （RSD = 1.50 % ）. CONCLUSION： The ointments were convenient in preparation technique, and simple and accurate in determination.

关 键 词：吲哚美辛 羟丙基-Β-环糊精包合物 软膏 制备 含量测定 

分 类 号：R944.21[医药卫生—药剂学] R927.2[医药卫生—药学]