控制释放亲水骨架系统的药物释放动力学研究  

Release kinetic study of controlled-release hydrophilic matrix system

作　　者：李献文[1] 邱阳[2] 

机构地区：[1]闽江学院化学化工系,福建福州350108 [2]中国科学技术大学化学与材料科学学院,安徽合肥230026

出　　处：《西北药学杂志》2007年第2期70-72,共3页Northwest Pharmaceutical Journal

摘　　要：目的研究以羟丙基甲基纤维素(HPMC)为基材的茶碱片剂在体外溶出的动力学规律。方法采用搅拌桨法测试茶碱从亲水骨架片中的溶出速率,并对测量数据进行线性回归分析。结果该骨架片的茶碱释放更适合于用时间的1/2次方模型表示。结论茶碱控制释放的主要机理是药物分子在基材中的扩散。Objective To study the release kinetics of theophylline from the hydroxypropyl methylcellulose （HPMC） matrix tablets in vitro release test. Methods Paddle method was used to determine release rate of theophylline from the hydrophilic matrix system. Results The release of theophylline from the hydrophilic matrix system fit better to a square-root time model than to the zero-order model. Conclusion The diffusion of theophylline through the swollen layer of HPMC is proved to be the major release driving force.

关 键 词：释放动力学 控制释放 骨架体系 茶碱 

分 类 号：R913[医药卫生—药学]