阿霉素磁性毫微球的制备及其含量测定  

Preparation of doxorubicin-loaded magnetic microsphere and determination of doxorubicin content by HPLC

作　　者：吕凤娇[1] 许小平[1] 

机构地区：[1]福州大学化学化工学院,福州350002

出　　处：《海峡药学》2007年第3期16-19,共4页Strait Pharmaceutical Journal

基　　金：福建省科技计划重点资助项目(2005I010)〗

摘　　要：本文以阿霉素为模型药物,Fe3O4为磁核材料,单体乙烯吡咯烷酮为载体材料,通过反相乳液聚合方法制备了阿霉素磁性毫微粒,研究了制备过程中投药量以及NVP用量对药物包封率的影响,并对其体外释放性进行研究。结果发现阿霉素磁性毫微粒载药量随着阿霉素投入量的增加先是增加而后变化不大,而包封率则逐渐下降;阿霉素磁性毫微粒载药量随着载体材料用量的增加逐渐下降而包封率则不断增加。在体外释放研究中,毫微粒载药量越大,突释部分越大,累积释放速率也越大。Doxorubicin-loaded magnetic microparticles, using doxorubicin as model drug, Fe3O4 as core and vinylpyrrolidone as matix material, were prepared by inverse emulsion polymerization in this paper. The drug encapsulation efficiency （EE） and the drug release kinetics under in vitro conditions were measured by high performance liquid chromatography with fluorescence detection （HPLC-FLD）. The results are that, with the doxorubicin dosage increasing, the doxorubicin loading is increasing while the drug encapsulation efficiency is decreasing. Again the doxorubicin loading is decreasing with the matrix material dosage increasing, while the drug encapsulation efficiency is increasing. The results showed that the greater the drug loading the greater the burst- drug, and the faster the release.

关 键 词：阿霉素 磁性 微球 高效液相色谱 荧光检测 

分 类 号：R927.2[医药卫生—药学]