乳化剂对阿司匹林微球制备的影响  

Preparation of polylactic acid enveloped aspirin microspheres and its release in vitro

作　　者：冼远芳[1] 侯瑞珍[1] 

机构地区：[1]长春工业大学化工学院,吉林长春130012

出　　处：《中国医院药学杂志》2007年第3期324-327,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:用溶剂挥发法以聚乳酸为载体制得阿司匹林聚乳酸微球。方法:选择不同的乳化剂,用正交设计安排实验。并以微球包埋率、载药量、表面形态、体外释放为指标优化微球的制备工艺。结果:按优化条件制得的微球包埋率39.5%,载药量7.25%,体外释药t1/2为3d。结论:制备微球缓释效果明显。OBJECTIVE Polyactic acid enveloped aspirin microspheres were prepared by the solvent evaportion method. METttODS The orthogonal tast of 3 factors and 3 levels was applied to optinize the preparation procedure of with indexes of particle appearance,drug content,rate of encapsulation. RESULTS Micropheres were obtained drug content of 7. 25% and en-cap sulated rate of 39. 5 %. t1/2 （in vitro）were 70 h. CONCLUSION The results showed the microspheres prepared by the method had obviously release effect.

关 键 词：阿司匹林 聚乳酸 乳化挥发法 正交实验 缓释微球 

分 类 号：R925[医药卫生—药学]