上海地区208名儿童CYP3A活性分布  

The distribution of CYP3A activity in 208 healthy children in Shanghai

作　　者：陆晓彤[1] 张顺国[1] 张健[1] 蒋樾廉[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092

出　　处：《中国医院药学杂志》2007年第3期336-339,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的：了解上海地区3岁儿童CYP3A酶活性的分布。方法：采用高效液相色谱法（HPLC）测定尿液中氢化可的松和6β-羟基氢化可的松的浓度，以6β-羟基氢化可的松／氢化可的松的浓度比来表示CYP3A酶的活性。结果：208名受栓者CYP3A酶的活性为4．0±1．9，其中男性为4．2±1．9，女性为3．7±1．8。结论：3岁儿童CYP3A酶活性无性别差异，正常值范围为1．13～13．77。OBJECTIVE To investigate the distribution of CYP3A activity in the children aged 3 in Shanghai,METHODS Urine concentrations of hydrocortisone and 6β-hydroxycortisol were determined by a high-performance liquid chromatography method. The urinary ratio of 6β-hydroxycortisol/hydrocortisone had been used as a noninvasive probe for human CYP3A. RESULTS The mean value of CYP3A activity in 208 measured was 4. 0 ± 1.9, and man 4. 2 ±1. 9, woman 3. 7 ± 1.8. CONCLUSION There is no difference of CYP3A activity in gender. The range of normal values is from 1.13 to 13.77.

关 键 词：CYP3A 氢化可的松 分布 尿液 

分 类 号：Q559.8[生物学—生物化学]