基因芯片技术与中药研究——中药基因组学  

Microarray and research of Chinese medications:pharmcogenomics of Chinese medications

作　　者：荆志伟[1] 王忠[1] 高思华 王永炎[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]国家中医药管理局科教司,北京100026

出　　处：《中国中药杂志》2007年第4期289-292,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(90209015);国家"十一五"科技支撑计划项目(2006038076128)

摘　　要：中药多成分、多途径、多靶点的作用特点决定了其系统化研究的趋势,基因芯片技术以其高通量、并行、高内涵的优势介入了现代中药研究。作者回顾了近3年来用于探索中药作用靶点、药物有效部位、中药材鉴定、新药物筛选等方面的新进展,结合中医学的理论指导,提出“中药基因组学”的发展趋势,以求探索中医药研究的纵深发展。The mechanism of Chinese medications have some characteristic such as multi-pathway, multi-components, multitargets and so on, which decide the direction of systems research. In the recent years, microarrays be concerned with the relative field of Chinese medications for its superiority of highthough, parallel and high-density. This paper mainly generalize the approach of these methods in the recent three years, such as finding effective target of Chinese medications, effective part of Chinese medications, checkup of Chinese medications, screening new drugs and so on. We suggest the concept of Pharmacogenomics of Chinese medications with the guidance of the theory of Chinese medications for further development of Chinese medications.

关 键 词：基因芯片 中药研究 中药基因组学 药物靶点 道地药材 中药材鉴定 新药筛选 

分 类 号：R28[医药卫生—中药学]