保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响  

Effects of Baogan Jiedu Granules on IL-18 and Apoptosis in Acute Liver Injury Mice Induced by Tripterygium Wilfordii Polyglycoside

作　　者：彭勃[1] 禄保平[1] 苗明三[1] 杨晓娜[1] 许家艳[1] 

机构地区：[1]河南中医学院肝病研究所,河南省郑州市金水路1号450008

出　　处：《中医杂志》2007年第2期169-171,共3页Journal of Traditional Chinese Medicine

基　　金：河南省科技攻关项目(0324410026)

摘　　要：目的探讨药物性肝损伤的发病机理及保肝解毒颗粒的作用机制。方法60只小鼠随机分为6组,分别以相应剂量药物灌胃5天,再以雷公藤多苷灌胃造模,检测小鼠血清丙氨酸氨基转移酶(ALT)、血清门冬氨酸氨基转移酶(AST)和白介素18(IL-18)水平及肝细胞凋亡情况。结果模型组IL-18明显升高,肝细胞凋亡严重;保肝解毒颗粒可有效降低ALT、AST和IL-18水平,并使肝细胞凋亡程度明显减轻。结论雷公藤多苷所致的急性肝损伤与IL-18和肝细胞凋亡密切相关;保肝解毒颗粒可通过降低-18水平、抑制肝细胞凋亡等起到防治肝脏损害的作用。Objective To explore the pathogenesis of drug-induced liver injury and the therapeutic mechanism of Baogan Jiedu Granules. Methods Totally 60 mice were randomly divided into 6 groups. They were treated with intragastrical perfusion of corresponding doses of drugs for 5 days,respectively and then were modeled by intragastrical perfusion of Tripterygium Wilfordii Polyglycoside. Serum ALT,AST and IL-18 levels and apoptosis of hepatic cells were detected. Results IL-18 level in model group increased obviously with severe apoptosis of hepatic cells. Baogan J iedu Granules could effectively decrease ALT,AST activities and IL-18 level with apoptosis of hepatic cells obviously improved. Conclusion Leigongteng Duodai-induced acute liver injury is closely correlated with IL-18 and apoptosis of hepatic cells. Baogan Jiedu Granules has therapeutic effect for liver injury through decreasing IL-18 level and inhibiting apioptosis of hepatic cells.

关 键 词：肝疾病 中医药疗法 细胞凋亡 保肝解毒颗粒 

分 类 号：R285[医药卫生—中药学]