CAIS法校正ICP-MS测定血铅浓度及同位素比值基体效应的研究  

CAIS Correction for Blood Matrix Effect on Determination of Lead Concentration and Isotope Ratio by ICP-MS

作　　者：曾静[1] 王晓燕[1,2] 刘虎生[1] 敦哲[3] 翟蕾[3] 王京宇[1,2] 

机构地区：[1]北京大学公共卫生学院 [2]北京大学医药卫生分析中心生命元素组学实验室,北京100083 [3]北京市海淀区疾病预防控制中心

出　　处：《光谱学与光谱分析》2007年第2期374-377,共4页Spectroscopy and Spectral Analysis

基　　金：北京市自然科学基金项目(7062041)资助

摘　　要：通过模拟全血基体,考察了基体效应对于ICP-MS测定铅浓度及铅同位素比值的影响,并应用CAIS法(common analyte internal standardization)对基体效应进行了校正。实验表明CAIS法适用于多元素复杂基体的校正,校正前及经传统内标法和CAIS法校正后铅浓度测量值与真值之间的相对误差分别为20%,8%,2%,而基体效应对铅同位素比值的影响及其校正作用均不明显;Tl和Dy作为内标的校正结果说明内标元素和被测元素在质量数和性质上的相近与否并不影响CAIS法校正效果;此外,CAIS法对于不同稀释倍数的血液基体都能达到好的校正效果;牛全血标准物质中铅的测定结果证明了CAIS法的可靠性和实用性。The research studied the influence of matrix effect on the determination of lead concentration and isotope ratio through simulating blood matrix, and its correction by common analyte internal standardization （CAIS） method. The experiment results showed that CAIS method was suitable for the multi-element-matrix. The relative errors between the determined and the true concentration values are 20 % （without correction）, 8 % （by conventional internal reference correction） and 2 % （by CAIS correction）, respectively. Otherwise, the influence of matrix effect and its correction for isotope ratio determination are not that obvious. Similarity of the mass number and properties between internal reference and analyte elements seems not important for CAIS correction, since very close correction results were obtained by using T1 and Dy as internal reference elements. Besides, correction results are not affected by different matrix dilution. Reliability and practicality of CAIS were proved by bovine blood stand- ard material determination.

关 键 词：CAIS 基体效应 铅 同位素比值 

分 类 号：O657.3[理学—分析化学]