高血压相关基因与运动防治的分子生物学基础  

Related Genes of Hypertension and Molecule Biology of Exercise Prevention and Cure

作　　者：赵杰修[1] 胡扬[2] 叶鸣[3] 

机构地区：[1]国家体育总局体育科学研究所,北京100061 [2]北京体育大学运动人体科学学院,北京100084 [3]首都体育学院运动人体科学系,北京100088

出　　处：《体育科学》2007年第2期58-66,共9页China Sport Science

摘　　要：高血压病是一种遗传性疾病,属于复杂性状疾病范畴,是“基因-基因”与“基因-环境”相互作用所致的多基因遗传性疾病。与高血压形成相关的部分基因主要是肾素、血管紧张素原基因、血管紧张素转换酶基因、原癌基因和抑癌基因、血管紧张素II的1型受体、内皮型一氧化氮合酶、α-内收蛋白、G蛋白β3亚基、激肽释放酶。运动防治高血压的分子生物学机理方面的研究还很少,仅仅对高血压某一领域进行了的部分研究、缺乏系统性和深入性。运动防治高血压的效果存在着明显的个体差异。近年来关于高血压个体的训练敏感性与基因多态性之间的研究已有报道,这对阐明运动防治高血压效果的个体差异机理以及制定合理的个性化运动处方很有意义。Hypertension is a polygene transmissibility illness with complexity trait. It is caused by reciprocity of gene-gene and gene-environment. Related genes of hypertension includes renin, angiotensinoge, tumor suppressor gene and oncogenes, angiotensin Ⅱ type 1 receptor, endothelial nitric oxide synthas, α-adducin, G-protein β3 subunit, kallikrein. At present, there were few molecule biology researches on exercise-preventing and curing hypertension, and the few non-systemic researches investigated some aspects of hypertension and exercise. In addition, effects of exercise on hypertension showed significant individual difference. Recently, there are some reports of exercise-sensitivity of personality and gene polymorphism, which will contribute to mechanism research of effects of exercise on hypertension and make rational and personal exercise prescription.

关 键 词：高血压 运动 分子生物学 防治 

分 类 号：G804.7[文化科学—运动人体科学]