开搏通对心肌缺血再灌注过程中肾素－血管紧张素系统的影响  

EFFECTS OF CAPTOPRIL ON CARDIAC RENIN ANGIOTENSIN SYSTEM IN MYOCARDIAL ISCHEMIC REPERFUSION RATS

作　　者：任晓燕[1,2,3] 马镇江[1,2,3] 刘乃奎 常英姿[1,2,3] 苏静怡 

机构地区：[1]青岛医学院病理生理学教研室 [2]中国人民解放军空军青岛疗养院三科 [3]北京医科大学心血管研究室

出　　处：《青岛医学院学报》1996年第3期200-202,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨开搏通对心肌缺血再灌注过程中肾素－血管紧张素系统的影响。②方法采用离体大鼠心脏Ｌａｎｇｅｎｄｏｒｆ灌注模型，观察了缺血、缺血再灌注及开搏通再灌注组心肌组织血管紧张素转换酶、血管紧张素Ⅱ及乳酸脱氢酶活性的变化。③结果与对照组相比，缺血组及再灌注组血管紧张素转换酶的活性、血管紧张素Ⅱ的含量均升高；开搏通组血管紧张素转换酶的活性及血管紧张素Ⅱ的含量均降低。乳酸脱氢酶的活性再灌注组明显升高，开搏通组则降低。④结论心肌肾素－血管紧张素参与再灌注损伤。Objective To study the effect of captopril on cardiac renin angiotensin system in myocardial ischemic reperfusion rats. Method The Langendroff perfuse model of isolated rat heart was used to study the activity changes of cardiac angiotensin converting enzyme(ACE), angiotensin Ⅱ(ANG Ⅱ) and lactate dehydrogenase (LDH)during ischemic and reperfusion period. Result The activities of ACE and ANG Ⅱ were increased in ischemic and ischemic reperfusion(I R) groups and decreased in captopril group. The activity of LDH was increased in I R group and reduced in captopril group. Conclusion The results of the study suggest that cardiac renin angiotensin system is involved in ischemic reperfusion injury. Captopril has protective effects on ischemic myocardium.

关 键 词：心肌缺血 再灌注损伤 血管紧张素 开搏通 PAS 

分 类 号：R541.4[医药卫生—心血管疾病] R364.12[医药卫生—内科学]