α-2b干扰素、布地奈德与沙丁胺醇治疗婴幼儿毛细支气管炎  

Treatment with interferon α-2b,budesonide and salbutamol on infant bronchiolitis

作　　者：陈啸洪[1] 夏云[2] 李华浚[1] 陈青春[1] 

机构地区：[1]浙江省绍兴市人民医院儿科,绍兴312000 [2]浙江省绍兴文理学院医学院

出　　处：《临床医学》2007年第2期3-5,共3页Clinical Medicine

摘　　要：目的探讨治疗婴幼儿毛细支气管炎的方法，观察α-2b干扰素（r—IFNα-2b）、布地奈德和沙丁胺醇综合治疗婴幼儿毛细支气管炎的疗效。方法选择2003年1月-2006年1月收住院的136例毛细支气管患儿按1：2的比例随机分为两组。对照组45例，采用常规治疗；观察组91例，在常规治疗的基础上加用α-2b干扰素肌注，布地奈德混悬液与沙丁胺醇雾化液氧气雾化吸人。用ELISA法分别检测血浆IgE、由介素-4（IL-4）、白介素-5（IL-5）、γ干扰素（γ-IFN），观察治疗前后IgE、IL-4、IL-5、1-IFN的水平及临床症状、体征、住院时间。结果毛细支气管炎患儿血浆IL-4、IL-5、IgE水平在急性期（治疗前）明显升高，γ—1FN水半明显降低（P〈0．01）。治疗后：观察组血浆IL-4、IL-5、IgE水平明显下降，γ-IFN水平较治疗前升高，差异均仃统计学意义（P〈0．01）。对照组血浆IL-4、IL-5、IgE水平较治疗前下降，γ-IFN水平较治疗前升高，但变化程度不如观察组明显，IL-4、IL-5、IgE水平高于正常组的水平，γ-IFN水平低于正常组的水平，差异有统计学意义（P〈0．01）。在临床症状、体征及住院时间上，观察组明显优于对照组（P〈0．01）。结论α-2b干扰素、布地奈德、沙丁胺醇综合治疗小儿毛细支气管炎可使患儿血中有关指标明显改善，缩短疗程。Objective To explore the treatment of infants bronchiolitis and observe the therapeutic effectiveness of interferon α - 2b, budesonide and salbutamol on infant bronchiolitis. Methods One hundred and thirty - six patienis between January 2003 and January 2006 were randomly divided into two groups by the ratio of 1 to 2. Control group （45 cases） received conventional treatment. Observation group （91 cases） were treated with interferon α -2b and oxygen atomized inhalation with budesonide suspension and salbutamol atomized liquid. The levels of IgE, IL - 4, IL - 5,γ- IFN and clinical symptoms, physical signs and length of stay were determined before and after treatment. Results The levels of IL - 4, IL - 5, IgE were significantly higher （ P 〈 0. 01 ） and the levels of γ - IFN were significantly lower （ P 〈 0. 01 ） in the acute episode period in infant bronchiolitis compared with normal infants. In observation group,The levels of were significantly lower （ P 〈 0. 01 ） and the levels of γ - IFN were significantly higher （ P 〈 0. 01 ） in the remission period compared with acute episode period. There was a little change in control group. In physical syptoms, physical signs and length of stay, patients of observation group were better than those in control group obviously. Conclusion Combined treatment with interferon at -2b, budesonide and salbutamol on infant bronchiolitis can improve the related indices of blood significantly and shorten the period of treatment.

关 键 词：毛细支气管炎 Α-2B干扰素 布地奈德 沙丁胺醇 治疗 

分 类 号：R725.6[医药卫生—儿科]