14型肺炎球菌荚膜多糖-破伤风类毒素结合疫苗的研制  

Preparation of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to TT

作　　者：张萍[1] 王欣茹[1] 侯亚莉[1] 张新庄[1] 杜琳[1] 谢贵林[1] 

机构地区：[1]兰州生物制品研究所,兰州730046

出　　处：《微生物学免疫学进展》2007年第1期1-4,共4页Progress In Microbiology and Immunology

摘　　要：将14型肺炎球菌的荚膜多糖(PS)与破伤风类毒素(TT)通过化学方法结合,制备成多糖-蛋白结合疫苗(PS14-TT)。用该结合疫苗免疫小鼠,在小鼠体内产生了高滴度的PS-IgG抗体和TT-IgG抗体,且再次注射后有加强应答效应,表明制备的结合疫苗保留了完好的抗原性,具有胸腺依赖性抗原的特性。The capsular polysaccharide of pneumecoecus type 14 was bound to TT in order to prepare a conjugate vaccine. It showed that anti-PS14 IgG and anti-TT IgG antibodies could be elicited at a higher level in the mice when immunized by PS14-TT. It also showed the boosted responses when subcutaneously injected with the same preparation. The results indicate that the conjugate vaccine maintain the good antigenicity and the characters related to T cell dependent antigens.

关 键 词：肺炎球菌 荚膜多糖 破伤风类毒素 结合疫苗 

分 类 号：R392[医药卫生—免疫学]