D－二聚体胶乳试验在血栓性疾病早期诊断中的应用  

Application of D-dimer latex assay in the early diagnosis of thrombotic diseases

作　　者：安肇璋[1] 杨绍敏[1] 张曼华[1] 

机构地区：[1]昆明市第一人民医院检验科

出　　处：《上海医学检验杂志》1996年第3期160-161,共2页Shanghai Journal of Medical Laboratory Sciences

摘　　要：采用Ｄ－二聚体（Ｄ－Ｄ）胶乳试验，检测５２例正常人，３０例心血管疾病、２８例肺心病、２５例脑梗塞、２０例ＤＩＣ、４１例脑外科手术和２０例其它疾病的患者。结果表明Ｄ－Ｄ水平除肺心病缓解期和脑外科手术前与正常对照比较Ｐ＞０．０５外，其余均有显著性差异（Ｐ＜０．００５，Ｐ＜０．０５）。Ｄ－Ｄ胶乳法与传统的止凝血检验相比较，对血栓性疾病的早期诊断有较高的特异性（６０．３％）和敏感性（９０．６％），能提示继发性纤溶亢进，具有一定的临床意义和实用价值。Plasma D-dimer was determined by latex assay in patients with cardiovascular diseases (30), cor pulmonale(28), cerebral infarction (25), disseminated intravascular coagulation (20), surgical operation of brain (41) and other diseases (20), and normal adults (52). Results showed that in comparison to normal adults the D-dimer levels exhibited significant difference (P<0. 05, P<0.005) in all above diseases expect in alleviatory period of cor pulmonale and before surgical operation of brain (P>0. 05). D-dimer latex assay has higher specificity (60.3%) and sensitivity (90.6%) for the early diagnosis of thrombotic diseases than the traditional assays.

关 键 词：血栓性疾病 诊断 D-B胶乳试验 纤维蛋白溶解 

分 类 号：R543.04[医药卫生—心血管疾病] R446.11[医药卫生—内科学]