酒精在人体内的代谢动力学研究  

STUDY OF ALCOHOL PHARMACOKINETICS IN HUMAN BODY

作　　者：赖江华[1] 胡炳蔚[1] 

机构地区：[1]西安医科大学法医学系,710061

出　　处：《中国法医学杂志》1996年第1期1-5,共5页Chinese Journal of Forensic Medicine

摘　　要：将16名健康男性志愿者随机分为两组，分别按含酒精0．65g／kg和0．80g／kg体重的剂量给予酒精饮料，于酒后不同时间点采取静脉血样。用乙醇脱氨酶（ADH）氧化分析法测血样酒精浓度（BAC），所得浓度-时间数据经用药代动力学软件分析拟合。结果表明，酒精在人体内的代谢符合非线性消除伴一级吸收的一室开放模型。据此，作者建立了描述酒精在人体内动态变化规律的数学模型。经验证，该模型符合度良好，可用于司法实践。Sixteen normal male volunteers were randomly divided into two groups and were asked to drink two doses of ethanol 0. 65g/kg and 0. 80g/kg alcoholic beverage seperately. Then the venous blood sample was collected at the different time. A ADH enzyme catalyzed method was used to determine the blood alcohol concentration (BAC). The experimental concentration-time (C-T) data was calcu-lated by the pharmacokinetics software,the result showed that the metabolism of alcohol confirmed with 1 -compartment nonlinear pharmacokinetics with first absorption model. According to this, a mathematic formula of alcoholic dynamics in human body was established. After the test of human ex-periment, the model was found suitable in the practice of forensic medicine.

关 键 词：酒精 代谢动力学 非线性消除 

分 类 号：R89[医药卫生—法医学] R595.602[医药卫生—临床医学]