早期心肌梗死心肌细胞内纤维连接蛋白的免疫组化观察  

IMMUNOHISTOCHEMICAL DEMONSTRATION OF FIBRONECTIN IN CARDIOMYOCYTES OF EARLY MYOCARDIAL INFARCTION

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 

机构地区：[1]中山医科大学法医学系,广州510089

出　　处：《中国法医学杂志》1996年第1期14-17,共4页Chinese Journal of Forensic Medicine

摘　　要：应用免疫组化LSAB法，对34例尸检心脏标本，进行心肌细胞内纤维连接蛋白用于早期心肌梗死死后诊断的研究。其中尸检及组织学证实心肌梗死5例，其心肌细胞内纤维连接蛋白均呈阳性。冠状动脉有硬化或冠状动脉口狭窄的可疑心肌梗死18例，其中15例心肌细胞内纤维连接蛋白阳性。非心性死亡对照组11例，心肌细胞内纤维连接蛋白均呈阴性。实验表明，心肌细胞内纤维连接蛋白免疫组化观察在急性心肌梗死，尤其是早期心肌梗死死后诊断上具有重要价值，为早期心肌梗死的死后诊断提供了一个实用方法。Immunohistochemical study of fibronectin (FN ) was first per formed on 34 autopsy hearts for postmortem diagnosis of early myocardial infarction with LSAB-method. The results showed that FN was positive in cardiomyocytes of all 5 difinite myocardial infarctions. Among 18 suspected myocardial infarctions, FN was positive in 15 cases. However,FN was negative in cardiomyocytes of all 11 non-cardiac death controls. These facts suggest that FN in cardiomyocytes is a re1iable marker of acute my-ocardial infarction, especially of early myocardial infarction, and could be used as a new, sensitive method for the postmortem diagnosis of acute myocardial infarction.

关 键 词：早期 心肌梗死 纤维连接蛋白 免疫组化 

分 类 号：R542.220.4[医药卫生—心血管疾病]