湖南地区反复自然流产患者HLA-A、B抗原分布及免疫治疗的初步报道  

Studies on Distribution of HLA-A/B Antigens and Treatment in Recurrent Spontaneous Abortion

作　　者：李立新[1] 罗奇志[1] 余平[1] 孙科柱[1] 余俊龙[1] 

机构地区：[1]中南大学湘雅医学院免疫学教研室,湖南长沙410078

出　　处：《实用预防医学》2007年第1期28-29,共2页Practical Preventive Medicine

摘　　要：目的研究原因不明的反复自然流产(RSA)患者与HLA-A、B抗原的相关性以及找到一种行之有效的治疗方法。方法对47对确诊为原发性反复自然流产病人夫妇及54对生育正常夫妇用血清学方法进行HLA-A/B分型,比较两组夫妇间的抗原相容性。然后用丈夫或献血员的淋巴细胞对病人进行主动免疫治疗。结果RSA夫妇间HLA-A/B抗原相容性增大(RR=3.13,χ2=7.76,P<0.01);HLA-B35抗原频率在RSA病人组(0/108)低于生育正常妇女组(10/94)(RR=0.05,P=0.00156,Pc=0.028);47例病人中的28例采用丈夫或献血员肘静脉血40ml分离淋巴细胞行主动免疫治疗,20例妊娠成功,1例失访,成功率为74.07%。结论HLA抗原相容性增加与RSA有关;HLA-B35对RSA具有疾病保护作用;采用丈夫或献血员淋巴细胞治疗RSA是一种有效的方法。Objective The HLA- A/B sharing in women with recurrent spontaneous abortion（RSA） and its effective treatment method were studied. Methods HLA typing in 47 couples with unexplained fetal loses were compared with those of 54 couples of normal controls, and their husbands＇ or donors＇ leukocytes suspension were applied for treatment. Results HLA sharing was significantly decreased in the patients（57.45 % ） as compared with the normal controls（RR = 3.13, χ^2 = 7.76, P〈0.01 ）. HLA- B35 antigen frequency in the patients（Old08） was significantly lower than that of the controls（10/94 ; RR = 0.05, P = 0. 00156, Pc = 0.028）. Successful pregnaney was obtained in 74.07 % of these RSA women after immunization with their husbands＇ or donors＇ lymphocytes suspension. Conclusion RSA is associated with increased HLA sharing. HLA- B35 contributes the protective role in RSA. Application of husband＇s or donors＇ leukocytes Suspension in treatment of RSA is effective.

关 键 词：习惯性流产 抗原相容性 免疫治疗 

分 类 号：R714.21[医药卫生—妇产科学]